A Risk Prediction Flowchart of Vancomycin-Induced Acute Kidney Injury to Use When Starting Vancomycin Administration : A Multicenter Retrospective Study

Miyai, Takayuki; Imai, Shungo; Kashiwagi, Hitoshi; Sato, Yuki; Kadomura, Shota; Yoshida, Kenji; Yoshimura, Eri; Teraya, Toshiaki; Tsujimoto, Takashi; Kawamoto, Yukari; Itoh, Tatsuya; Ueno, Hidefumi; Goto, Yoshikazu; Takekuma, Yoh; Sugawara, Mitsuru

A Risk Prediction Flowchart of Vancomycin-Induced Acute Kidney Injury to Use When Starting Vancomycin Administration : A Multicenter Retrospective Study

Miyai, Takayuki; Imai, Shungo; Kashiwagi, Hitoshi et al.

Antibiotics, 2020, 9(12), 920

Permalink : https://hdl.handle.net/2115/80398

このアイテムのアクセス数:610件（2026-10-10 00:16 集計）

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論文情報

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アクセス権	open access
URI	https://hdl.handle.net/2115/80398
タイトル	A Risk Prediction Flowchart of Vancomycin-Induced Acute Kidney Injury to Use When Starting Vancomycin Administration : A Multicenter Retrospective Study
著者	Miyai, Takayuki ; Imai, Shungo ; Kashiwagi, Hitoshi ; Sato, Yuki ; Kadomura, Shota ; Yoshida, Kenji ; Yoshimura, Eri ; Teraya, Toshiaki ; Tsujimoto, Takashi ; Kawamoto, Yukari ; Itoh, Tatsuya ; Ueno, Hidefumi ; Goto, Yoshikazu ; Takekuma, Yoh ; Sugawara, Mitsuru
著者名 Miyai, Takayuki
e-Rad_Researcher 40845070 著者名 Imai, Shungo
e-Rad_Researcher 60510609 著者名 Kashiwagi, Hitoshi
e-Rad_Researcher 00564981 著者名 Sato, Yuki
著者名 Kadomura, Shota
著者名 Yoshida, Kenji
著者名 Yoshimura, Eri
著者名 Teraya, Toshiaki
著者名 Tsujimoto, Takashi
著者名 Kawamoto, Yukari
著者名 Itoh, Tatsuya
著者名 Ueno, Hidefumi
著者名 Goto, Yoshikazu
e-Rad_Researcher 00396293 著者名 Takekuma, Yoh
e-Rad_Researcher 60332467 著者名 Sugawara, Mitsuru
言語	英語
キーワード	vancomycin
	therapeutic drug monitoring
	decision tree analysis
	acute kidney injury
発行日	2020-12-18
出版者	MDPI
収録物名	Antibiotics
巻(号)	9(12)
ページ	920
抄録	We previously constructed a risk prediction model of vancomycin (VCM)-associated nephrotoxicity for use when performing initial therapeutic drug monitoring (TDM), using decision tree analysis. However, we could not build a model to be used at the time of initial administration due to insufficient sample size. Therefore, we performed a multicenter study at four hospitals in Japan. We investigated patients who received VCM intravenously at a standard dose from the first day until the initial TDM from November 2011 to March 2019. Acute kidney injury (AKI) was defined according to the criteria established by the "Kidney disease: Improving global outcomes" group. We extracted potential risk factors that could be evaluated on the day of initial administration and constructed a flowchart using a chi-squared automatic interaction detection algorithm. Among 843 patients, 115 (13.6%) developed AKI. The flowchart comprised three splitting variables (concomitant drugs (vasopressor drugs and tazobactam/piperacillin) and body mass index >= 30) and four subgroups. The incidence rates of AKI ranged from 9.34 to 36.8%, and they were classified as low-, intermediate-, and high-risk groups. The accuracy of flowchart was judged appropriate (86.4%). We successfully constructed a simple flowchart predicting VCM-induced AKI to be used when starting VCM administration.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution 4.0 International
PISSN	2079-6382
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.3390/antibiotics9120920