Evaluation of Baloxavir Marboxil and Peramivir for the Treatment of High Pathogenicity Avian Influenza in Chickens

Twabela, Augustin; Okamatsu, Masatoshi; Matsuno, Keita; Isoda, Norikazu; Sakoda, Yoshihiro

Evaluation of Baloxavir Marboxil and Peramivir for the Treatment of High Pathogenicity Avian Influenza in Chickens

Twabela, Augustin; Okamatsu, Masatoshi; Matsuno, Keita et al.

Viruses-Basel, 2020, 12(12), 1407

Permalink : https://hdl.handle.net/2115/80404

このアイテムのアクセス数:657件（2026-08-11 02:45 集計）

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https://doi.org/10.3390/v12121407			36

論文情報

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アクセス権	open access
URI	https://hdl.handle.net/2115/80404
タイトル	Evaluation of Baloxavir Marboxil and Peramivir for the Treatment of High Pathogenicity Avian Influenza in Chickens
著者	Twabela, Augustin ; Okamatsu, Masatoshi ; Matsuno, Keita ; Isoda, Norikazu ; Sakoda, Yoshihiro
著者名 Twabela, Augustin
e-Rad_Researcher 00507163 著者名 Okamatsu, Masatoshi
e-Rad_Researcher 40753306 著者名 Matsuno, Keita
e-Rad_Researcher 80615732 著者名 Isoda, Norikazu
e-Rad_Researcher 40333637 著者名 Sakoda, Yoshihiro
言語	英語
キーワード	baloxavir marboxil
	peramivir
	treatment
	high pathogenicity avian influenza
	chicken model
発行日	2020-12
出版者	MDPI
収録物名	Viruses-Basel
巻(号)	12(12)
ページ	1407
抄録	Control measures in the case of high pathogenicity avian influenza (HPAI) outbreaks in poultry include culling, surveillance, and biosecurity; wild birds in captivity may also be culled, although some rare bird species should be rescued for conservation. In this study, two anti-influenza drugs, baloxavir marboxil (BXM) and peramivir (PR), used in humans, were examined in treating HPAI in birds, using chickens as a model. Chickens were infected with H5N6 HPAI virus and were treated immediately or 24 h from challenge with 20 mg/kg BXM or PR twice a day for five days. As per our findings, BXM significantly reduced virus replication in organs and provided full protection to chickens compared with that induced by PR. In the 24-h-delayed treatment, neither drug completely inhibited virus replication nor ensured the survival of infected chickens. A single administration of 2.5 mg/kg of BXM was determined as the minimum dose required to fully protect chickens from HPAI virus; the concentration of baloxavir acid, the active form of BXM, in chicken blood at this dose was sufficient for a 48 h antiviral effect post-administration. Thus, these data can be a starting point for the use of BXM and PR in treating captive wild birds infected with HPAI virus.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution 4.0 International
PISSN	1999-4915
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.3390/v12121407