Second Case of Deceased Donor Liver Transplantation in a Patient Co-infected with HIV and HCV in Japan : Special Reference to the Management of Complicated Coagulopathy Due to a Diverse Spectrum of Preformed Anti-HLA Antibodies

Kawamura, Norio; Goto, Ryoichi; Koshizuka, Yasuyuki; Watanabe, Masaaki; Suzuki, Tomomi; Endo, Tomoyuki; Kondo, Takeshi; Taketomi, Akinobu; Shimamura, Tsuyoshi

Second Case of Deceased Donor Liver Transplantation in a Patient Co-infected with HIV and HCV in Japan : Special Reference to the Management of Complicated Coagulopathy Due to a Diverse Spectrum of Preformed Anti-HLA Antibodies

Kawamura, Norio; Goto, Ryoichi; Koshizuka, Yasuyuki et al.

Japanese journal of infectious diseases, 2020, 73(5), 369-372

Permalink : https://hdl.handle.net/2115/80437

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https://doi.org/10.7883/yoken.JJID.2019.487			14

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アクセス権	open access
URI	https://hdl.handle.net/2115/80437
タイトル	Second Case of Deceased Donor Liver Transplantation in a Patient Co-infected with HIV and HCV in Japan : Special Reference to the Management of Complicated Coagulopathy Due to a Diverse Spectrum of Preformed Anti-HLA Antibodies
著者	Kawamura, Norio ; Goto, Ryoichi ; Koshizuka, Yasuyuki ; Watanabe, Masaaki ; Suzuki, Tomomi ; Endo, Tomoyuki ; Kondo, Takeshi ; Taketomi, Akinobu ; Shimamura, Tsuyoshi
e-Rad_Researcher 20746953 著者名 Kawamura, Norio
e-Rad_Researcher 10645287 著者名 Goto, Ryoichi
著者名 Koshizuka, Yasuyuki
e-Rad_Researcher 40789848 著者名 Watanabe, Masaaki
e-Rad_Researcher 70374238 著者名 Suzuki, Tomomi
著者名 Endo, Tomoyuki
著者名 Kondo, Takeshi
e-Rad_Researcher 70363364 著者名 Taketomi, Akinobu
e-Rad_Researcher 00333617 著者名 Shimamura, Tsuyoshi
言語	英語
発行日	2020-09
出版者	国立感染症研究所（National Institute of Infectious Diseases, Japan）
収録物名	Japanese journal of infectious diseases
巻(号)	73(5)
ページ	369-372
抄録	We report the second case of deceased donor liver transplantation in a patient co-infected with human immunodeficiency virus (HIV) and hepatitis C virus (HCV) in Japan. A 48-year-old patient with hemophilia A was infected with HIV and HCV through contaminated factor VIII concentrate in his childhood and developed cirrhosis and hepatocellular carcinoma. The patient was on the transplant list for a deceased donor liver. The patient had broad spectrum anti-HLA class I and II antibodies, which may be attributed to repeated whole blood transfusions in the past. Catastrophic coagulopathy during the surgery was predicted because of the underlying hemophilic status and severe thrombocytopenia requiring HLA-matched platelet products, which are difficult to obtain quickly. To maintain adequate platelet counts (> 5 x 10(4)/mu L) while awaiting liver transplantation, a thrombopoietin receptor agonist and rituximab were administered. During surgery, factor VIII concentrate was administered according to a previously planned protocol. Adequate hemostasis was obtained, and the operation was completed without uncontrollable coagulopathy. The postoperative course was uneventful, and the patient was discharged on postoperative day 41. Detailed planning is required for surgical patients with hemophilia and HIV/HCV cirrhosis, especially for those with a diverse spectrum of anti-HLA antibodies.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
PISSN	1344-6304
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.7883/yoken.JJID.2019.487