Nivolumab-induced immune thrombocytopenia in a patient with malignant pleural mesothelioma

Sakakibara-Konishi, Jun; Sato, Mineyoshi; Sato, Michiko Takimoto; Kasahara, Kohei; Onozawa, Masahiro; Mizugaki, Hidenori; Kikuchi, Eiki; Asahina, Hajime; Shinagawa, Naofumi; Konno, Satoshi

Nivolumab-induced immune thrombocytopenia in a patient with malignant pleural mesothelioma

Sakakibara-Konishi, Jun; Sato, Mineyoshi; Sato, Michiko Takimoto et al.

Respiratory Medicine Case Reports, 2020, 31, 101170

Permalink : https://hdl.handle.net/2115/80442

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アクセス権	open access
URI	https://hdl.handle.net/2115/80442
タイトル	Nivolumab-induced immune thrombocytopenia in a patient with malignant pleural mesothelioma
著者	Sakakibara-Konishi, Jun ; Sato, Mineyoshi ; Sato, Michiko Takimoto ; Kasahara, Kohei ; Onozawa, Masahiro ; Mizugaki, Hidenori ; Kikuchi, Eiki ; Asahina, Hajime ; Shinagawa, Naofumi ; Konno, Satoshi
e-Rad_Researcher 50374278 著者名 Sakakibara-Konishi, Jun
著者名 Sato, Mineyoshi
著者名 Sato, Michiko Takimoto
著者名 Kasahara, Kohei
著者名 Onozawa, Masahiro
e-Rad_Researcher 40752689 著者名 Mizugaki, Hidenori
e-Rad_Researcher 60463741 著者名 Kikuchi, Eiki
e-Rad_Researcher 90374298 著者名 Asahina, Hajime
e-Rad_Researcher 20431372 著者名 Shinagawa, Naofumi
e-Rad_Researcher 20399835 著者名 Konno, Satoshi
言語	英語
キーワード	Malignant pleural mesothelioma
	Nivolumab
	Immune thrombocytopenia
発行日	2020
出版者	Elsevier
収録物名	Respiratory Medicine Case Reports
巻(号)	31
ページ	101170
抄録	Malignant pleural mesothelioma (MPM) is a rare and highly aggressive tumor. Nivolumab showed durable antitumor effect in patients with recurrent MPM and was approved for those patients in Japan in 2018. Immune related adverse event (irAE) is occurred in various organs and is suggestive to be related to better outcome of nivolumab. Frequency of hematological irAE is low and there are few reports about hematological irAE and association between irAE and outcome of nivolumab in patients with MPM. We present a case of recurrent MPM who responded to nivolumab treatment and experienced nivolumab-induced immune thrombocytopenia (ITP). Although high dose dexamethasone was administered and platelet count increased transiently, re-administration of dexamethasone was required to maintain normal count of platelet. The careful and intensive management of ITP treatment is necessary in cases who show no response or relapse to initial glucocorticoids treatment. This is the first report about nivolumab-induced ITP and association with response to nivolumab in MPM.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
PISSN	2213-0071
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1016/j.rmcr.2020.101170