Interleukin-34 expression in ovarian cancer : a possible correlation with disease progression

Endo, Hiraku; Hama, Naoki; Baghdadi, Muhammad; Ishikawa, Kozo; Otsuka, Ryo; Wada, Haruka; Asano, Hiroshi; Endo, Daisuke; Konno, Yosuke; Kato, Tatsuya; Watari, Hidemichi; Tozawa, Akiko; Suzuki, Nao; Yokose, Tomoyuki; Takano, Atsushi; Kato, Hisamori; Miyagi, Yohei; Daigo, Yataro; Seino, Ken-Ichiro

Interleukin-34 expression in ovarian cancer : a possible correlation with disease progression

Endo, Hiraku; Hama, Naoki; Baghdadi, Muhammad et al.

International immunology, 2020, 32(3), 175-186

Permalink : https://hdl.handle.net/2115/80503

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アクセス権	open access
URI	https://hdl.handle.net/2115/80503
タイトル	Interleukin-34 expression in ovarian cancer : a possible correlation with disease progression
著者	Endo, Hiraku ; Hama, Naoki ; Baghdadi, Muhammad ; Ishikawa, Kozo ; Otsuka, Ryo ; Wada, Haruka ; Asano, Hiroshi ; Endo, Daisuke ; Konno, Yosuke ; Kato, Tatsuya ; Watari, Hidemichi ; Tozawa, Akiko ; Suzuki, Nao ; Yokose, Tomoyuki ; Takano, Atsushi ; Kato, Hisamori ; Miyagi, Yohei ; Daigo, Yataro ; Seino, Ken-Ichiro
著者名 Endo, Hiraku
著者名 Hama, Naoki
e-Rad_Researcher 60711570 著者名 Baghdadi, Muhammad
e-Rad_Researcher 20624795 著者名 Ishikawa, Kozo
著者名 Otsuka, Ryo
e-Rad_Researcher 70392181 著者名 Wada, Haruka
著者名 Asano, Hiroshi
著者名 Endo, Daisuke
e-Rad_Researcher 10572703 著者名 Konno, Yosuke
著者名 Kato, Tatsuya
e-Rad_Researcher 10344508 著者名 Watari, Hidemichi
e-Rad_Researcher 90569865 著者名 Tozawa, Akiko
e-Rad_Researcher 90246356 著者名 Suzuki, Nao
e-Rad_Researcher 10221665 著者名 Yokose, Tomoyuki
e-Rad_Researcher 50582607 著者名 Takano, Atsushi
著者名 Kato, Hisamori
e-Rad_Researcher 00254194 著者名 Miyagi, Yohei
e-Rad_Researcher 30345029 著者名 Daigo, Yataro
e-Rad_Researcher 20312845 著者名 Seino, Ken-Ichiro
言語	英語
キーワード	disease stage
	interleukin-34
	ovarian cancer
	overall survival
	progression-free survival
発行日	2020-03
出版者	Oxford University Press
収録物名	International immunology
巻(号)	32(3)
ページ	175-186
抄録	Ovarian cancer is the second-most lethal gynecological malignancy and the seventh-commonest cause of cancer-related death in women around the world. Most of the ovarian cancer patients are diagnosed at advanced stages and suffer from recurrence after primary cytoreductive surgery and standard first-line chemotherapy. Thus, the successful management of ovarian cancer patients requires the identification of factors that contribute to progression and relapse. Interleukin-34 (IL-34) is a novel cytokine that acts as a tissue-specific ligand of colony-stimulating factor-1 receptor (CSF-1R). In cancer, IL-34 exerts pro-tumorigenic functions that promote tumor growth, metastasis, angiogenesis, immune suppression and therapeutic resistance. In this study, we evaluate the impact of IL-34 on progression and survival of ovarian cancer patients. First, IL-34 was found to be expressed in several human ovarian cancer cell lines and cancer tissues from patients. The expression of IL-34 was enhanced by cytotoxic chemotherapy in ovarian cancer cell lines and cancer tissues from chemotherapy-treated ovarian cancer patients. Importantly, high IL-34 expression correlated with worse progression-free survival (PFS) and overall survival in different cohorts. The assessment of PFS based on a combination between IL34 expression and other related genes such as CSF1R and CD163 helped further to reach more statistical significance compared with IL34 alone. Furthermore, in the murine ovarian cancer cell HM-1 in vivo model, it was suggested that IL-34-derived tumor cells was correlated with tumor progression and survival by modulating the immune environment. Collectively, these findings indicate a possible correlation between IL-34 expression and disease progression in ovarian cancer patients and the mouse model.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	This is a pre-copyedited, author-produced version of an article accepted for publication in International immunology following peer review. The version of record Hiraku Endo, Naoki Hama, Muhammad Baghdadi, Kozo Ishikawa, Ryo Otsuka, Haruka Wada, Hiroshi Asano, Daisuke Endo, Yosuke Konno, Tatsuya Kato, Hidemichi Watari, Akiko Tozawa, Nao Suzuki, Tomoyuki Yokose, Atsushi Takano, Hisamori Kato, Yohei Miyagi, Yataro Daigo, Ken-ichiro Seino, Interleukin-34 expression in ovarian cancer: a possible correlation with disease progression, International Immunology, Volume 32, Issue 3, March 2020, Pages 175-186., is available online at: https://doi.org/10.1093/intimm/dxz074
PISSN	0953-8178
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1093/intimm/dxz074