Association between low body mass index and increased 28-day mortality of severe sepsis in Japanese cohorts

Oami, Takehiko; Karasawa, Satoshi; Shimada, Tadanaga; Nakada, Taka-aki; Abe, Toshikazu; Ogura, Hiroshi; Shiraishi, Atsushi; Kushimoto, Shigeki; Saitoh, Daizoh; Fujishima, Seitaro; Mayumi, Toshihiko; Shiino, Yasukazu; Tarui, Takehiko; Hifumi, Toru; Otomo, Yasuhiro; Okamoto, Kohji; Umemura, Yutaka; Kotani, Joji; Sakamoto, Yuichiro; Sasaki, Junichi; Shiraishi, Shin-ichiro; Takuma, Kiyotsugu; Tsuruta, Ryosuke; Hagiwara, Akiyoshi; Yamakawa, Kazuma; Masuno, Tomohiko; Takeyama, Naoshi; Yamashita, Norio; Ikeda, Hiroto; Ueyama, Masashi; Fujimi, Satoshi; Gando, Satoshi

Association between low body mass index and increased 28-day mortality of severe sepsis in Japanese cohorts

Oami, Takehiko; Karasawa, Satoshi; Shimada, Tadanaga et al.

Scientific reports, 2021, 11(1), 1615

Permalink : https://hdl.handle.net/2115/80526

このアイテムのアクセス数:613件（2026-08-20 06:54 集計）

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https://doi.org/10.1038/s41598-020-80284-3			16

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アクセス権	open access
URI	https://hdl.handle.net/2115/80526
タイトル	Association between low body mass index and increased 28-day mortality of severe sepsis in Japanese cohorts
著者	Oami, Takehiko ; Karasawa, Satoshi ; Shimada, Tadanaga ; Nakada, Taka-aki ; Abe, Toshikazu ; Ogura, Hiroshi ; Shiraishi, Atsushi ; Kushimoto, Shigeki ; Saitoh, Daizoh ; Fujishima, Seitaro ; Mayumi, Toshihiko ; Shiino, Yasukazu ; Tarui, Takehiko ; Hifumi, Toru ; Otomo, Yasuhiro ; Okamoto, Kohji ; Umemura, Yutaka ; Kotani, Joji ; Sakamoto, Yuichiro ; Sasaki, Junichi ; Shiraishi, Shin-ichiro ; Takuma, Kiyotsugu ; Tsuruta, Ryosuke ; Hagiwara, Akiyoshi ; Yamakawa, Kazuma ; Masuno, Tomohiko ; Takeyama, Naoshi ; Yamashita, Norio ; Ikeda, Hiroto ; Ueyama, Masashi ; Fujimi, Satoshi ; Gando, Satoshi
e-Rad_Researcher 70527887 著者名 Oami, Takehiko
e-Rad_Researcher 20646393 著者名 Karasawa, Satoshi
e-Rad_Researcher 40436423 著者名 Shimada, Tadanaga
e-Rad_Researcher 20375794 著者名 Nakada, Taka-aki
e-Rad_Researcher 70633973 著者名 Abe, Toshikazu
e-Rad_Researcher 70301265 著者名 Ogura, Hiroshi
e-Rad_Researcher 40401343 著者名 Shiraishi, Atsushi
e-Rad_Researcher 50195434 著者名 Kushimoto, Shigeki
e-Rad_Researcher 90531632 著者名 Saitoh, Daizoh
e-Rad_Researcher 00173419 著者名 Fujishima, Seitaro
e-Rad_Researcher 90281071 著者名 Mayumi, Toshihiko
著者名 Shiino, Yasukazu
著者名 Tarui, Takehiko
e-Rad_Researcher 30383756 著者名 Hifumi, Toru
e-Rad_Researcher 40176946 著者名 Otomo, Yasuhiro
著者名 Okamoto, Kohji
e-Rad_Researcher 20743561 著者名 Umemura, Yutaka
e-Rad_Researcher 80360270 著者名 Kotani, Joji
e-Rad_Researcher 20366678 著者名 Sakamoto, Yuichiro
e-Rad_Researcher 90235250 著者名 Sasaki, Junichi
e-Rad_Researcher 90386243 著者名 Shiraishi, Shin-ichiro
e-Rad_Researcher 30216824 著者名 Takuma, Kiyotsugu
e-Rad_Researcher 30263768 著者名 Tsuruta, Ryosuke
著者名 Hagiwara, Akiyoshi
e-Rad_Researcher 50597507 著者名 Yamakawa, Kazuma
e-Rad_Researcher 00318528 著者名 Masuno, Tomohiko
e-Rad_Researcher 00155053 著者名 Takeyama, Naoshi
著者名 Yamashita, Norio
著者名 Ikeda, Hiroto
著者名 Ueyama, Masashi
著者名 Fujimi, Satoshi
e-Rad_Researcher 30125306 著者名 Gando, Satoshi
言語	英語
発行日	2021-01-15
出版者	Nature Research
収録物名	Scientific reports
巻(号)	11(1)
ページ	1615
抄録	Current research regarding the association between body mass index (BMI) and altered clinical outcomes of sepsis in Asian populations is insufficient. We investigated the association between BMI and clinical outcomes using two Japanese cohorts of severe sepsis (derivation cohort, Chiba University Hospital, n=614; validation cohort, multicenter cohort, n=1561). Participants were categorized into the underweight (BMI<18.5) and non-underweight (BMI<greater than or equal to>18.5) groups. The primary outcome was 28-day mortality. Univariate analysis of the derivation cohort indicated increased 28-day mortality trend in the underweight group compared to the non-underweight group (underweight 24.4% [20/82 cases] vs. non-underweight 16.0% [85/532 cases]; p=0.060). In the primary analysis, multivariate analysis adjusted for baseline imbalance revealed that patients in the underweight group had a significantly increased 28-day mortality compared to those in the non-underweight group (p=0.031, adjusted odds ratio [OR] 1.91, 95% confidence interval [CI] 1.06-3.46). In a repeated analysis using a multicenter validation cohort (underweight n=343, non-underweight n=1218), patients in the underweight group had a significantly increased 28-day mortality compared to those in the non-underweight group (p=0.045, OR 1.40, 95% CI 1.00-1.97). In conclusion, patients with a BMI<18.5 had a significantly increased 28-day mortality compared to those with a BMI<greater than or equal to>18.5 in Japanese cohorts with severe sepsis.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution 4.0 International
PISSN	2045-2322
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1038/s41598-020-80284-3