Post-translational Wnt receptor regulation : Is the fog slowly clearing?

Tsukiyama, Tadasuke; Koo, Bon-Kyoung; Hatakeyama, Shigetsugu

Post-translational Wnt receptor regulation : Is the fog slowly clearing?

Tsukiyama, Tadasuke; Koo, Bon-Kyoung; Hatakeyama, Shigetsugu

Bioessays, 2021, 43(4), e2000297

Permalink : https://hdl.handle.net/2115/80631

このアイテムのアクセス数:603件（2026-10-16 21:42 集計）

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ファイル	フォーマット	サイズ	閲覧回数	説明
https://doi.org/10.1002/bies.202000297			89

論文情報

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アクセス権	open access
URI	https://hdl.handle.net/2115/80631
タイトル	Post-translational Wnt receptor regulation : Is the fog slowly clearing?
著者	Tsukiyama, Tadasuke ; Koo, Bon-Kyoung ; Hatakeyama, Shigetsugu
e-Rad_Researcher 20399819 著者名 Tsukiyama, Tadasuke
著者名 Koo, Bon-Kyoung
e-Rad_Researcher 70294973 著者名 Hatakeyama, Shigetsugu
言語	英語
キーワード	CRCs
	Fzd
	RNF43
	tumorigenesis
	ubiquitination
	Wnt signaling
	ZNRF3
発行日	2021-04
出版者	John Wiley & Sons
収録物名	Bioessays
巻(号)	43(4)
ページ	e2000297
抄録	Wnt signaling plays pivotal roles during our entire lives, from conception to death, through the regulation of morphogenesis in developing embryos and the maintenance of tissue homeostasis in adults. The regulation of Wnt signaling occurs on several levels: at the receptor level on the plasma membrane, at the beta-catenin protein level in the cytoplasm, and through transcriptional regulation in the nucleus. Several recent studies have focused on the mechanisms of Wnt receptor regulation, following the discovery that the Wnt receptor frizzled (Fzd) is a target of the ubiquitin ligases, RNF43 and ZNRF3. RNF43 and ZNRF3 are homologous genes that are mutated in several cancers. The details underlying their mechanism of action continue to unfold, while at the same time raising many new questions. In this review, we discuss advances and controversies in our understanding of Wnt receptor regulation.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
PISSN	0265-9247
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1002/bies.202000297