Enhanced dispersion stability of gold nanoparticles by the physisorption of cyclic poly(ethylene glycol)

Wang, Yubo; Quinsaat, Jose Enrico Q.; Ono, Tomoko; Maeki, Masatoshi; Tokeshi, Manabu; Isono, Takuya; Tajima, Kenji; Satoh, Toshifumi; Sato, Shin-ichiro; Miura, Yutaka; Yamamoto, Takuya

Enhanced dispersion stability of gold nanoparticles by the physisorption of cyclic poly(ethylene glycol)

Wang, Yubo; Quinsaat, Jose Enrico Q.; Ono, Tomoko et al.

Nature communications, 2020, 11(1), 6089

Permalink : https://hdl.handle.net/2115/80639

このアイテムのアクセス数:487件（2026-08-16 08:29 集計）

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https://doi.org/10.1038/s41467-020-19947-8			18

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アクセス権	open access
URI	https://hdl.handle.net/2115/80639
タイトル	Enhanced dispersion stability of gold nanoparticles by the physisorption of cyclic poly(ethylene glycol)
著者	Wang, Yubo ; Quinsaat, Jose Enrico Q. ; Ono, Tomoko ; Maeki, Masatoshi ; Tokeshi, Manabu ; Isono, Takuya ; Tajima, Kenji ; Satoh, Toshifumi ; Sato, Shin-ichiro ; Miura, Yutaka ; Yamamoto, Takuya
著者名 Wang, Yubo
著者名 Quinsaat, Jose Enrico Q.
著者名 Ono, Tomoko
著者名 Maeki, Masatoshi
e-Rad_Researcher 60311437 著者名 Tokeshi, Manabu
著者名 Isono, Takuya
e-Rad_Researcher 00271643 著者名 Tajima, Kenji
e-Rad_Researcher 80291235 著者名 Satoh, Toshifumi
e-Rad_Researcher 10262601 著者名 Sato, Shin-ichiro
著者名 Miura, Yutaka
e-Rad_Researcher 30525986 著者名 Yamamoto, Takuya
言語	英語
発行日	2020-11-30
出版者	Nature Research
収録物名	Nature communications
巻(号)	11(1)
ページ	6089
抄録	Nano-sized metal particles are attracting much interest in industrial and biomedical applications due to the recent progress and development of nanotechnology, and the surface-modifications by appropriate polymers are key techniques to stably express their characteristics. Herein, we applied cyclic poly(ethylene glycol) (c-PEG), having no chemical inhomogeneity, to provide a polymer topology-dependent stabilization for the surface-modification of gold nanoparticles (AuNPs) through physisorption. By simply mixing c-PEG, but not linear counterparts, enables AuNPs to maintain dispersibility through freezing, lyophilization, or heating. Surprisingly, c-PEG endowed AuNPs with even better dispersion stability than thiolated PEG (HS-PEG-OMe). The stronger affinity of c-PEG was confirmed by DLS,.-potential, and FT-IR. Furthermore, the c-PEG system exhibited prolonged blood circulation and enhanced tumor accumulation in mice. Our data suggests that c-PEG induces physisorption on AuNPs, supplying sufficient stability toward bio-medical applications, and would be an alternative approach to the gold-sulfur chemisorption.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution 4.0 International
PISSN	2041-1723
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1038/s41467-020-19947-8