BXSB/MpJ-Yaa mouse model of systemic autoimmune disease shows increased apoptotic germ cells in stage XII of the seminiferous epithelial cycle

Otani, Yuki; Ichii, Osamu; Masum, Abdul; Kimura, Junpei; Nakamura, Teppei; Elewa, Yaser Hosny Ali; Kon, Yasuhiro

BXSB/MpJ-Yaa mouse model of systemic autoimmune disease shows increased apoptotic germ cells in stage XII of the seminiferous epithelial cycle

Otani, Yuki; Ichii, Osamu; Masum, Abdul et al.

Cell and tissue research, 2020, 381, 203-216

Permalink : https://hdl.handle.net/2115/80847

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アクセス権	open access
URI	https://hdl.handle.net/2115/80847
タイトル	BXSB/MpJ-Yaa mouse model of systemic autoimmune disease shows increased apoptotic germ cells in stage XII of the seminiferous epithelial cycle
著者	Otani, Yuki ; Ichii, Osamu ; Masum, Abdul ; Kimura, Junpei ; Nakamura, Teppei ; Elewa, Yaser Hosny Ali ; Kon, Yasuhiro
著者名 Otani, Yuki
e-Rad_Researcher 60547769 著者名 Ichii, Osamu
著者名 Masum, Abdul
著者名 Kimura, Junpei
著者名 Nakamura, Teppei
ORCID 0000-0002-7347-4587 著者名 Elewa, Yaser Hosny Ali
e-Rad_Researcher 10178402 著者名 Kon, Yasuhiro
言語	英語
キーワード	Systemic autoimmune disease
	Male infertility
	Spermatogenesis
	Apoptosis
	Meiosis
発行日	2020-04-04
出版者	Springer
収録物名	Cell and tissue research
巻(号)	381
ページ	203-216
抄録	In mammals, the reproductive system and autoimmunity regulate mutual functions. Importantly, systemic autoimmune diseases are thought to cause male infertility but the underlying pathological mechanism remains unclear. In this study, the morpho-function of the testes in BXSB/MpJ-Yaa mice was analyzed as a representative mouse model for systemic autoimmune diseases to investigate the effect of excessive autoimmunity on spermatogenesis. At 12 and 24 weeks of age, BXSB/MpJ-Yaa mice showed splenomegaly and increased levels of serum autoantibodies, whereas no controls showed a similar autoimmune condition. In histological analysis, the enlarged lumen of the seminiferous tubules accompanied with scarce spermatozoa in the epididymal ducts were observed in some of the BXSB/MpJ-Yaa and BXSB/MpJ mice but not in C57BL/6N mice. Histoplanimetrical analysis revealed significantly increased residual bodies and apoptotic germ cells in the seminiferous tubules in BXSB/MpJ-Yaa testes without apparent inflammation. Notably, in stage XII of the seminiferous epithelial cycles, the apoptotic germ cell number was remarkably increased, showing a significant correlation with the indices of systemic autoimmune disease in BXSB/MpJ-Yaa mice. Furthermore, the Sertoli cell number was reduced at the early disease stage, which likely caused subsequent morphological changes in BXSB/MpJ-Yaa testes. Thus, our histological study revealed the altered morphologies of BXSB/MpJ-Yaa testes, which were not observed in controls and statistical analysis suggested the effects of an autoimmune condition on this phenotype, particularly the apoptosis of meiotic germ cells. BXSB/MpJ-Yaa mice were shown to be an efficient model to study the relationship between systemic autoimmune disease and the local reproductive system.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	This is a post-peer-review, pre-copyedit version of an article published in Cell and tissue research. The final authenticated version is available online at: http://doi.org/10.1007/s00441-020-03190-0
PISSN	0302-766X
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1007/s00441-020-03190-0