Association of inflammatory biomarkers with long-term outcomes after curative surgery for mass-forming intrahepatic cholangiocarcinoma

Ohira, Masafumi; Yoshizumi, Tomoharu; Yugawa, Kyohei; Kosai-Fujimoto, Yukiko; Inokuchi, Shoichi; Motomura, Takashi; Mano, Yohei; Toshima, Takeo; Itoh, Shinji; Harada, Noboru; Ikegami, Toru; Soejima, Yuji; Taketomi, Akinobu; Mori, Masaki

Association of inflammatory biomarkers with long-term outcomes after curative surgery for mass-forming intrahepatic cholangiocarcinoma

Ohira, Masafumi; Yoshizumi, Tomoharu; Yugawa, Kyohei et al.

Surgery today, 2020, 50(4), 379-388

Permalink : https://hdl.handle.net/2115/80858

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アクセス権	open access
URI	https://hdl.handle.net/2115/80858
タイトル	Association of inflammatory biomarkers with long-term outcomes after curative surgery for mass-forming intrahepatic cholangiocarcinoma
著者	Ohira, Masafumi ; Yoshizumi, Tomoharu ; Yugawa, Kyohei ; Kosai-Fujimoto, Yukiko ; Inokuchi, Shoichi ; Motomura, Takashi ; Mano, Yohei ; Toshima, Takeo ; Itoh, Shinji ; Harada, Noboru ; Ikegami, Toru ; Soejima, Yuji ; Taketomi, Akinobu ; Mori, Masaki
著者名 Ohira, Masafumi
e-Rad_Researcher 80363373 著者名 Yoshizumi, Tomoharu
著者名 Yugawa, Kyohei
著者名 Kosai-Fujimoto, Yukiko
著者名 Inokuchi, Shoichi
e-Rad_Researcher 50719507 著者名 Motomura, Takashi
著者名 Mano, Yohei
e-Rad_Researcher 40608965 著者名 Toshima, Takeo
e-Rad_Researcher 90382423 著者名 Itoh, Shinji
e-Rad_Researcher 80419580 著者名 Harada, Noboru
e-Rad_Researcher 80363373 著者名 Ikegami, Toru
著者名 Soejima, Yuji
e-Rad_Researcher 70363364 著者名 Taketomi, Akinobu
e-Rad_Researcher 70190999 著者名 Mori, Masaki
言語	英語
キーワード	Inflammatory biomarker
	Intrahepatic cholangiocarcinoma
	Long-term outcome
発行日	2020-04
出版者	Springer
収録物名	Surgery today
巻(号)	50(4)
ページ	379-388
抄録	Purpose Inflammatory biomarkers such as the neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR), and platelet-to-lymphocyte ratio (PLR) are reportedly predictive of the long-term outcomes of several cancers. We evaluated their correlations with the post-surgical long-term outcomes of patients with mass-forming (MF) intrahepatic cholangiocarcinoma (ICC). Methods The subjects of this study were 52 patients who underwent hepatic resection for MF-ICC at our hospital. We measured the cutoff values of NLR, LMR and PLR, using receiver operating characteristic curves, and compared the survival rates of patients with high vs. those with low values. We also evaluated a prognostic scoring system based on significant inflammatory biomarkers. Results The cutoff values for NLR, LMR, and PLR were 1.93, 4.78, and 98, respectively. The high-NLR and low-LMR groups had significantly worse prognoses than the low-NLR and high-LMR groups. We designed a scoring system using the inflammation score (IS) based on NLR and LMR values, stratifying patients into three groups with scores of 0, 1, or 2. The IS was significantly correlated with overall survival (OS), with 5-year survival rates by the IS score of 100% for 0, 61% for 1, and 32% for 2 (P = 0.011). The IS was found to be an independent predictor of OS in multivariate analysis. Conclusions Our IS scoring system may predict long-term outcomes after surgery for MF-ICC.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	This is a post-peer-review, pre-copyedit version of an article published in Surgery Today. The final authenticated version is available online at: http://dx.doi.org/10.1007/s00595-019-01905-7
PISSN	0941-1291
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1007/s00595-019-01905-7