Evaluation of the ameliorative effect of Spirulina (Arthrospira platensis) supplementation on parameters relating to lead poisoning and obesity in C57BL/6J mice

Nakata, Hokuto; Nakayama, Shouta M. M.; Kataba, Andrew; Yohannes, Yared Beyene; Ikenaka, Yoshinori; Ishizuka, Mayumi

Evaluation of the ameliorative effect of Spirulina (Arthrospira platensis) supplementation on parameters relating to lead poisoning and obesity in C57BL/6J mice

Nakata, Hokuto; Nakayama, Shouta M. M.; Kataba, Andrew et al.

Journal of functional foods, 2021, 77, 104344

Permalink : https://hdl.handle.net/2115/81070

このアイテムのアクセス数:554件（2026-08-10 02:01 集計）

閲覧可能ファイル

ファイル	フォーマット	サイズ	閲覧回数	説明
https://doi.org/10.1016/j.jff.2020.104344			16

論文情報

ファイル出力 EndNote Basic出力 Mendeley出力

アクセス権	open access
URI	https://hdl.handle.net/2115/81070
タイトル	Evaluation of the ameliorative effect of Spirulina (Arthrospira platensis) supplementation on parameters relating to lead poisoning and obesity in C57BL/6J mice
著者	Nakata, Hokuto ; Nakayama, Shouta M. M. ; Kataba, Andrew ; Yohannes, Yared Beyene ; Ikenaka, Yoshinori ; Ishizuka, Mayumi
e-Rad_Researcher 60815273 著者名 Nakata, Hokuto
e-Rad_Researcher 90647629 著者名 Nakayama, Shouta M. M.
著者名 Kataba, Andrew
著者名 Yohannes, Yared Beyene
e-Rad_Researcher 40543509 著者名 Ikenaka, Yoshinori
e-Rad_Researcher 50332474 著者名 Ishizuka, Mayumi
言語	英語
キーワード	Lead poisoning
	Obesity prevention
	Spirulina
	Cost-effective
	C57BL/6J
発行日	2021-02
出版者	Elsevier
収録物名	Journal of functional foods
巻(号)	77
ページ	104344
抄録	The current study aimed to validate the possible ameliorative effects of Spirulina (Arthrospira platensis) on lead poisoning and obesity using C57BL/6J mice. After a treatment period, we performed metal analyses, as well as hematocrit and plasma biochemical parameter measurements, and assayed oxidative stress markers and erythrocyte 6-aminolevulinic acid dehydratase (ALAD) activity. Our results highlighted the effectiveness of Spirulina in improving anemia status with the normalization of hematocrit levels and ALAD activity ratios, even in mice that exhibited obesity in addition to lead poisoning. Spirulina treatment also decreased epididymal white adipose tissue weight and increased plasma high-density lipoprotein levels, which are normally reduced after lead exposure. However, most of the studied plasma biochemical parameters and oxidative stress markers did not show large changes after treatment, likely because of the short duration of treatment. Further studies with longer-term exposures are required to validate the usefulness of Spirulina suggested in the present study.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
PISSN	1756-4646
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1016/j.jff.2020.104344