Combination of alcohol and glucose consumption as a risk to induce reactive hypoglycemia

Oba‐Yamamoto, Chiho; Takeuchi, Jun; Nakamura, Akinobu; Takikawa, Ryoko; Ozaki, Ayano; Nomoto, Hiroshi; Kameda, Hiraku; Cho, Kyu Yong; Atsumi, Tatsuya; Miyoshi, Hideaki

Combination of alcohol and glucose consumption as a risk to induce reactive hypoglycemia

Oba‐Yamamoto, Chiho; Takeuchi, Jun; Nakamura, Akinobu et al.

Journal of Diabetes Investigation, 2021, 12(4), 651-657

Permalink : https://hdl.handle.net/2115/81111

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アクセス権	open access
URI	https://hdl.handle.net/2115/81111
タイトル	Combination of alcohol and glucose consumption as a risk to induce reactive hypoglycemia
著者	Oba‐Yamamoto, Chiho ; Takeuchi, Jun ; Nakamura, Akinobu ; Takikawa, Ryoko ; Ozaki, Ayano ; Nomoto, Hiroshi ; Kameda, Hiraku ; Cho, Kyu Yong ; Atsumi, Tatsuya ; Miyoshi, Hideaki
著者名 Oba‐Yamamoto, Chiho
著者名 Takeuchi, Jun
e-Rad_Researcher 70552420 著者名 Nakamura, Akinobu
著者名 Takikawa, Ryoko
著者名 Ozaki, Ayano
e-Rad_Researcher 50862330 著者名 Nomoto, Hiroshi
e-Rad_Researcher 20826127 著者名 Kameda, Hiraku
著者名 Cho, Kyu Yong
e-Rad_Researcher 20301905 著者名 Atsumi, Tatsuya
e-Rad_Researcher 30360902 著者名 Miyoshi, Hideaki
言語	英語
キーワード	Alcohol
	Hypoglycemia
	Oral glucosetolerance test
発行日	2021-04
出版者	John Wiley & Sons
収録物名	Journal of Diabetes Investigation
巻(号)	12(4)
ページ	651-657
抄録	Aims/Introduction Alcohol consumption has been reported to cause hypoglycemia. However, the mechanism involved has not been unequivocally established. This study comprised healthy volunteers. We carried out a prospective trial to compare the effects of glucose and alcohol consumption, alone or in combination, on glucose and lipid metabolism. Materials and Methods A 75‐g oral glucose tolerance test (OGTT), a combined 75‐g glucose plus 20‐g alcohol tolerance test (OGATT) and a 20‐g alcohol tolerance test (OATT) were carried out in the participants. Plasma glucose, insulin, triglyceride and ethanol concentrations during each test were compared. Results We studied 10 participants. Their plasma glucose concentrations 15 and 30 min after the intake of 75 g of glucose were significantly higher during the OGATT than the OGTT. Hypoglycemia occurred in five participants after the OGATT, which was significantly more frequently than after the OGTT (P = 0.046). Hypoglycemia did not occur after the OATT, and the ethanol concentration was significantly lower after the OGATT than the OATT. The changes in triglyceride concentration from 30 min after the consumption of 75 g of glucose were significantly greater during the OGATT than the OGTT. The plasma insulin concentrations peaked after 60 min during both the OGTT and OGATT, and were significantly higher during the OGATT (P = 0.047). There were no differences between the two interventions in the Matsuda or disposition indexes. Conclusions Hypoglycemia occurred more frequently after the simultaneous consumption of alcohol plus glucose than after the consumption of glucose alone, suggesting that alcohol in the combination of glucose induces reactive hypoglycemia.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution-NonCommercial 4.0 International
PISSN	2040-1116
EISSN	2040-1124
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1111/jdi.13375