Analgesic effects of indomethacin spray on drug-induced oral mucositis pain in patients with cancer: A single-arm cross-sectional study

Hata, Hironobu; Takada, Shinya; Sato, Jun; Yoshikawa, Kazuhito; Imamachi, Kenji; Edo, Minako; Sagawa, Tamotsu; Fujikawa, Koshi; Ueda, Michihiro; Matsuzaka, Masashi; Kitagawa, Yoshimasa

Analgesic effects of indomethacin spray on drug-induced oral mucositis pain in patients with cancer: A single-arm cross-sectional study

Hata, Hironobu; Takada, Shinya; Sato, Jun et al.

Special care in dentistry, 2021, 41(4), 498-504

Permalink : https://hdl.handle.net/2115/81152

このアイテムのアクセス数:527件（2026-08-17 23:26 集計）

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ファイル	フォーマット	サイズ	閲覧回数	説明
https://doi.org/10.1111/scd.12587			23

論文情報

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アクセス権	open access
URI	https://hdl.handle.net/2115/81152
タイトル	Analgesic effects of indomethacin spray on drug-induced oral mucositis pain in patients with cancer: A single-arm cross-sectional study
著者	Hata, Hironobu ; Takada, Shinya ; Sato, Jun ; Yoshikawa, Kazuhito ; Imamachi, Kenji ; Edo, Minako ; Sagawa, Tamotsu ; Fujikawa, Koshi ; Ueda, Michihiro ; Matsuzaka, Masashi ; Kitagawa, Yoshimasa
e-Rad_Researcher 70450830 著者名 Hata, Hironobu
著者名 Takada, Shinya
e-Rad_Researcher 60319069 著者名 Sato, Jun
e-Rad_Researcher 00637267 著者名 Yoshikawa, Kazuhito
e-Rad_Researcher 40779873 著者名 Imamachi, Kenji
著者名 Edo, Minako
著者名 Sagawa, Tamotsu
著者名 Fujikawa, Koshi
著者名 Ueda, Michihiro
e-Rad_Researcher 70431434 著者名 Matsuzaka, Masashi
e-Rad_Researcher 00224957 著者名 Kitagawa, Yoshimasa
言語	英語
キーワード	analgesic effect
	cancer therapy
	indomethacin spray
	oral mucositis pain
	quality of life
発行日	2021-03-18
出版者	John Wiley & Sons
収録物名	Special care in dentistry
巻(号)	41(4)
ページ	498-504
抄録	Aims: Symptomatic treatment is insufficient for chemotherapy- or targeted therapy-induced oral mucositis (OM) pain, and benzydamine mouthwash is not commercially available in Japan. We evaluated the analgesic effects of an in-hospital preparation of 0.25% indomethacin spray (IMS) on anticancer drug-induced OM pain. Methods: This single-arm prospective trial enrolled 20 patients (median age 62.0 years) with OM and numerical rating scale scores of >= 5 who were undergoing chemotherapy or targeted therapy in our hospital. Pain scores were recorded using a visual analog scale (VAS) before and 30 min after IMS administration. Pain relief (PR) scores were recorded at 15, 30, and 60 min after IMS administration; total PR after 60 min (TOTPAR(60)) was calculated, and the mean PR score after 3 days (PR3days) was determined. Results: The median (interquartile range) OM grade of the participants was 2.0 (2.0-2.3). The VAS score decreased significantly at 30 min after IMS administration (p = .001). The median (interquartile range) TOTPAR(60) and PR3days were 6.0 (3.8-7.3) and 2.0 (2.0-3.0), respectively. Conclusions: IMS helped improve patients' quality of life. The risk of systemic adverse effects was low because of the low dose administered. IMS effectively relieved anticancer drug-induced OM pain and may be useful for immediate self-medication.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
PISSN	0275-1879
関連情報	PMID 33735535
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1111/scd.12587