Local Administration of Low-Dose Nerve Growth Factor Antibody Reduced Pain in a Rat Osteoarthritis Model

Tian, Yuan; Onodera, Tomohiro; Terkawi, Mohamad Alaa; Iwasaki, Koji; Hishimura, Ryosuke; Liang, Dawei; Miyazaki, Takuji; Iwasaki, Norimasa

Local Administration of Low-Dose Nerve Growth Factor Antibody Reduced Pain in a Rat Osteoarthritis Model

Tian, Yuan; Onodera, Tomohiro; Terkawi, Mohamad Alaa et al.

International Journal of Molecular Sciences, 2021, 22(5), 2552

Permalink : https://hdl.handle.net/2115/81360

このアイテムのアクセス数:521件（2026-10-09 23:36 集計）

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https://doi.org/10.3390/ijms22052552			31

論文情報

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アクセス権	open access
URI	https://hdl.handle.net/2115/81360
タイトル	Local Administration of Low-Dose Nerve Growth Factor Antibody Reduced Pain in a Rat Osteoarthritis Model
著者	Tian, Yuan ; Onodera, Tomohiro ; Terkawi, Mohamad Alaa ; Iwasaki, Koji ; Hishimura, Ryosuke ; Liang, Dawei ; Miyazaki, Takuji ; Iwasaki, Norimasa
著者名 Tian, Yuan
e-Rad_Researcher 70547174 著者名 Onodera, Tomohiro
著者名 Terkawi, Mohamad Alaa
e-Rad_Researcher 40771895 著者名 Iwasaki, Koji
著者名 Hishimura, Ryosuke
著者名 Liang, Dawei
著者名 Miyazaki, Takuji
e-Rad_Researcher 30322803 著者名 Iwasaki, Norimasa
言語	英語
キーワード	osteoarthritis
	pain
	nerve growth factor (NGF)
	intra-articular injection
発行日	2021-03
出版者	MDPI
収録物名	International Journal of Molecular Sciences
巻(号)	22(5)
ページ	2552
抄録	Systemic injection of a nerve growth factor (NGF) antibody has been proven to have a significant relevance in relieving osteoarthritis (OA) pain, while its adverse effects remain a safety concern for patients. A local low-dose injection is thought to minimize adverse effects. In this study, OA was induced in an 8-week-old male Sprague-Dawley (SD) rat joint by monoiodoacetate (MIA) injection for 2 weeks, and the effect of weekly injections of low-dose (1, 10, and 100 mu g) NGF antibody or saline (control) was evaluated. Behavioral tests were performed, and at the end of week 6, all rats were sacrificed and their knee joints were collected for macroscopic and histological evaluations. Results showed that 100 mu g NGF antibody injection relieved pain in OA rats, as evidenced from improved weight-bearing performance but not allodynia. In contrast, no significant differences were observed in macroscopic and histological scores between rats from different groups, demonstrating that intra-articular treatment does not worsen OA progression. These results suggest that local administration yielded a low effective NGF antibody dose that may serve as an alternative approach to systemic injection for the treatment of patients with OA.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.3390/ijms22052552