Preoperative Texture Analysis Using C-11-Methionine Positron Emission Tomography Predicts Survival after Surgery for Glioma

Manabe, Osamu; Yamaguchi, Shigeru; Hirata, Kenji et al.

Diagnostics, 2021, 11(2), 189

Permalink : https://hdl.handle.net/2115/81368

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https://doi.org/10.3390/diagnostics11020189     23

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アクセス権
open access
URI
https://hdl.handle.net/2115/81368
タイトル
Preoperative Texture Analysis Using C-11-Methionine Positron Emission Tomography Predicts Survival after Surgery for Glioma
著者
Manabe, Osamu ; Yamaguchi, Shigeru ; Hirata, Kenji ; Kobayashi, Kentaro ; Kobayashi, Hiroyuki ; Terasaka, Shunsuke ; Toyonaga, Takuya ; Magota, Keiichi ; Kuge, Yuji ; Tamaki, Nagara ; Shiga, Tohru ; Kudo, Kohsuke
著者名
Manabe, Osamu
著者名
Yamaguchi, Shigeru
e-Rad_Researcher
30431365
著者名
Hirata, Kenji
著者名
Kobayashi, Kentaro
著者名
Kobayashi, Hiroyuki
著者名
Terasaka, Shunsuke
著者名
Toyonaga, Takuya
著者名
Magota, Keiichi
著者名
Kuge, Yuji
著者名
Tamaki, Nagara
著者名
Shiga, Tohru
著者名
Kudo, Kohsuke
言語
英語
キーワード
methionine
positron emission tomography
glioma
texture analysis
prognosis
発行日
2021-02
出版者
MDPI
収録物名
Diagnostics
巻(号)
11(2)
ページ
189
抄録
Background: Positron emission tomography with C-11-methionine (MET) is well established in the diagnostic work-up of malignant brain tumors. Texture analysis is a novel technique for extracting information regarding relationships among surrounding voxels, in order to quantify their inhomogeneity. This study evaluated whether the texture analysis of MET uptake has prognostic value for patients with glioma. Methods: We retrospectively analyzed adults with glioma who had undergone preoperative metabolic imaging at a single center. Tumors were delineated using a threshold of 1.3-fold of the mean standardized uptake value for the contralateral cortex, and then processed to calculate the texture features in glioma. Results: The study included 42 patients (median age: 56 years). The World Health Organization classifications were grade II (7 patients), grade III (17 patients), and grade IV (18 patients). Sixteen (16.1%) all-cause deaths were recorded during the median follow-up of 18.8 months. The univariate analyses revealed that overall survival (OS) was associated with age (hazard ratio (HR) 1.04, 95% confidence interval (CI) 1.01-1.08, p = 0.0093), tumor grade (HR 3.64, 95% CI 1.63-9.63, p = 0.0010), genetic status (p < 0.0001), low gray-level run emphasis (LGRE, calculated from the gray-level run-length matrix) (HR 2.30 x 10(11), 95% CI 737.11-4.23 x 10(19), p = 0.0096), and correlation (calculated from the gray-level co-occurrence matrix) (HR 5.17, 95% CI 1.07-20.93, p = 0.041). The multivariate analyses revealed OS was independently associated with LGRE and correlation. The survival curves were also significantly different (both log-rank p < 0.05). Conclusion: Textural features obtained using preoperative MET positron emission tomography may compliment the semi-quantitative assessment for prognostication in glioma cases.
資源タイプ
学術雑誌論文
出版タイプ
Version of Record
権利情報
Creative Commons Attribution 4.0 International
関連情報 (isIdenticalTo)
出版社版DOI
https://doi.org/10.3390/diagnostics11020189