MM2 cortical form of sporadic Creutzfeldt-Jakob disease without progressive dementia and akinetic mutism : A case deviating from current diagnostic criteria

Takahashi-Iwata, Ikuko; Yabe, Ichiro; Kudo, Akihiko; Eguchi, Katsuya; Wakita, Masahiro; Shirai, Shinichi; Matsushima, Masaaki; Toyoshima, Takanobu; Chiba, Susumu; Tanikawa, Satoshi; Tanaka, Shinya; Satoh, Katsuya; Kitamoto, Tetsuyuki; Sasaki, Hidenao

MM2 cortical form of sporadic Creutzfeldt-Jakob disease without progressive dementia and akinetic mutism : A case deviating from current diagnostic criteria

Takahashi-Iwata, Ikuko; Yabe, Ichiro; Kudo, Akihiko et al.

Journal of the neurological sciences, 2020, 412, 116759

Permalink : https://hdl.handle.net/2115/81396

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アクセス権	open access
URI	https://hdl.handle.net/2115/81396
タイトル	MM2 cortical form of sporadic Creutzfeldt-Jakob disease without progressive dementia and akinetic mutism : A case deviating from current diagnostic criteria
著者	Takahashi-Iwata, Ikuko ; Yabe, Ichiro ; Kudo, Akihiko ; Eguchi, Katsuya ; Wakita, Masahiro ; Shirai, Shinichi ; Matsushima, Masaaki ; Toyoshima, Takanobu ; Chiba, Susumu ; Tanikawa, Satoshi ; Tanaka, Shinya ; Satoh, Katsuya ; Kitamoto, Tetsuyuki ; Sasaki, Hidenao
著者名 Takahashi-Iwata, Ikuko
e-Rad_Researcher 60372273 著者名 Yabe, Ichiro
著者名 Kudo, Akihiko
著者名 Eguchi, Katsuya
著者名 Wakita, Masahiro
著者名 Shirai, Shinichi
著者名 Matsushima, Masaaki
著者名 Toyoshima, Takanobu
著者名 Chiba, Susumu
e-Rad_Researcher 00823353 著者名 Tanikawa, Satoshi
e-Rad_Researcher 70261287 著者名 Tanaka, Shinya
e-Rad_Researcher 70398147 著者名 Satoh, Katsuya
e-Rad_Researcher 20192560 著者名 Kitamoto, Tetsuyuki
e-Rad_Researcher 80281806 著者名 Sasaki, Hidenao
言語	英語
キーワード	Sporadic Creutzfeldt-Jakob disease
	Corticobasal syndrome
	MM2-cortical form
発行日	2020-05-15
出版者	Elsevier
収録物名	Journal of the neurological sciences
巻(号)	412
ページ	116759
抄録	Sporadic Creutzfeldt-Jakob disease (sCJD) is classified into six types based on codon 129 polymorphism in the PRNP gene and the protease-resistant prion-related protein, PrP [1,2]. This classification corresponds well with the clinical course and the pathological findings. MM2-cortical type sCJD (MM2C-sCJD) is clinically characterized by slow progressive dementia, increased levels of 14-3-3 protein in the cerebrospinal fluid (CSF), and no periodic synchronous discharge (PSD) in electroencephalography [3]. We report the case of a patient presented with chronic progressive cortical symptoms. Based on the initial clinical findings, corticobasal syndrome (CBS) was suspected although he did not develop akinetic mutism during the lifetime. The postmortem pathological and anatomical findings confirmed MM2C-sCJD. As per the existing diagnostic criteria, our case was difficult to diagnose during the patient’s lifetime. Therefore, this is an important case for considering future revisions of the diagnostic criteria for MM2C-sCJD.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
権利情報	© 2020, Elsevier. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
PISSN	0022-510X