Hyperpolarized C-13 Magnetic Resonance Imaging of Fumarate Metabolism by Parahydrogen-induced Polarization: A Proof-of-Concept in vivo Study

Stewart, Neil J.; Nakano, Hitomi; Sugai, Shuto; Tomohiro, Mitsushi; Kase, Yuki; Uchio, Yoshiki; Yamaguchi, Toru; Matsuo, Yujirou; Naganuma, Tatsuya; Takeda, Norihiko; Nishimura, Ikuya; Hirata, Hiroshi; Hashimoto, Takuya; Matsumoto, Shingo

Hyperpolarized C-13 Magnetic Resonance Imaging of Fumarate Metabolism by Parahydrogen-induced Polarization: A Proof-of-Concept in vivo Study

Stewart, Neil J.; Nakano, Hitomi; Sugai, Shuto et al.

ChemPhysChem, 2021, 22(10), 915-923

Permalink : https://hdl.handle.net/2115/81397

このアイテムのアクセス数:641件（2026-08-15 08:18 集計）

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https://doi.org/10.1002/cphc.202001038			33

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アクセス権	open access
URI	https://hdl.handle.net/2115/81397
タイトル	Hyperpolarized C-13 Magnetic Resonance Imaging of Fumarate Metabolism by Parahydrogen-induced Polarization: A Proof-of-Concept in vivo Study
著者	Stewart, Neil J. ; Nakano, Hitomi ; Sugai, Shuto ; Tomohiro, Mitsushi ; Kase, Yuki ; Uchio, Yoshiki ; Yamaguchi, Toru ; Matsuo, Yujirou ; Naganuma, Tatsuya ; Takeda, Norihiko ; Nishimura, Ikuya ; Hirata, Hiroshi ; Hashimoto, Takuya ; Matsumoto, Shingo
著者名 Stewart, Neil J.
著者名 Nakano, Hitomi
著者名 Sugai, Shuto
著者名 Tomohiro, Mitsushi
著者名 Kase, Yuki
著者名 Uchio, Yoshiki
著者名 Yamaguchi, Toru
著者名 Matsuo, Yujirou
著者名 Naganuma, Tatsuya
著者名 Takeda, Norihiko
e-Rad_Researcher 00228214 著者名 Nishimura, Ikuya
e-Rad_Researcher 60250958 著者名 Hirata, Hiroshi
著者名 Hashimoto, Takuya
e-Rad_Researcher 90741041 著者名 Matsumoto, Shingo
言語	英語
キーワード	density functional calculations
	fumarate
	hyperpolarized C-13 MRS/I
	matabolism
	parahydrogen-induced polarization
発行日	2021-05-17
出版者	Wiley-Blackwell
収録物名	ChemPhysChem
巻(号)	22(10)
ページ	915-923
抄録	Hyperpolarized [1-C-13]fumarate is a promising magnetic resonance imaging (MRI) biomarker for cellular necrosis, which plays an important role in various disease and cancerous pathological processes. To demonstrate the feasibility of MRI of [1-C-13]fumarate metabolism using parahydrogen-induced polarization (PHIP), a low-cost alternative to dissolution dynamic nuclear polarization (dDNP), a cost-effective and high-yield synthetic pathway of hydrogenation precursor [1-C-13]acetylenedicarboxylate (ADC) was developed. The trans-selectivity of the hydrogenation reaction of ADC using a ruthenium-based catalyst was elucidated employing density functional theory (DFT) simulations. A simple PHIP set-up was used to generate hyperpolarized [1-C-13]fumarate at sufficient C-13 polarization for ex vivo detection of hyperpolarized C-13 malate metabolized from fumarate in murine liver tissue homogenates, and in vivo C-13 MR spectroscopy and imaging in a murine model of acetaminophen-induced hepatitis.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution 4.0 International
PISSN	1439-4235
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1002/cphc.202001038