The association between hypoglycemia and glycemic variability in elderly patients with type 2 diabetes: a prospective observational study

Handa, Takahisa; Nakamura, Akinobu; Miya, Aika et al.

Diabetology and metabolic syndrome, 2021, 13(1), 37

Permalink : https://hdl.handle.net/2115/81593

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https://doi.org/10.1186/s13098-021-00656-1     15

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アクセス権
open access
URI
https://hdl.handle.net/2115/81593
タイトル
The association between hypoglycemia and glycemic variability in elderly patients with type 2 diabetes: a prospective observational study
著者
Handa, Takahisa ; Nakamura, Akinobu ; Miya, Aika ; Nomoto, Hiroshi ; Kameda, Hiraku ; Cho, Kyu Yong ; Nagai, So ; Yoshioka, Narihito ; Miyoshi, Hideaki ; Atsumi, Tatsuya
著者名
Handa, Takahisa
e-Rad_Researcher
70552420
著者名
Nakamura, Akinobu
著者名
Miya, Aika
著者名
Nomoto, Hiroshi
著者名
Kameda, Hiraku
著者名
Cho, Kyu Yong
著者名
Nagai, So
著者名
Yoshioka, Narihito
著者名
Miyoshi, Hideaki
著者名
Atsumi, Tatsuya
言語
英語
キーワード
Coefficient of variation
Continuous glucose monitoring
Hypoglycemia
発行日
2021-04-01
出版者
BioMed Central
収録物名
Diabetology and metabolic syndrome
巻(号)
13(1)
ページ
37
抄録
Background This study aimed to explore predictive factors of time below target glucose range (TBR) >= 1% among patients' characteristics and glycemic variability (GV) indices using continuous glucose monitoring data in elderly patients with type 2 diabetes. Methods We conducted a prospective observational study on 179 (71 female) Japanese outpatients with type 2 diabetes aged >= 65 years. The characteristics of the participants with TBR >= 1% were evaluated by multivariate logistic regression analysis. Receiver-operating characteristic (ROC) curve analyses of GV indices, comprising coefficient of variation (CV), standard deviation, and mean amplitude of glycemic excursions, were performed to identify the optimal index for the identification of patients with TBR >= 1%. Results In the multivariate logistic regression analysis, none of the clinical characteristics, including HbA1c and C-peptide index, were independent markers for TBR >= 1%, while all three GV indices showed significant associations with TBR >= 1%. Among the three GV indices, CV showed the best performance based on the area under the curve in the ROC curve analyses. Conclusions Among elderly patients with type 2 diabetes, CV reflected TBR >= 1% most appropriately among the GV indices examined. Trial registration UMIN-CTR: UMIN000029993. Registered 16 November 2017
資源タイプ
学術雑誌論文
出版タイプ
Version of Record
関連情報 (isIdenticalTo)
出版社版DOI
https://doi.org/10.1186/s13098-021-00656-1