DNA methylation of GFI1 as a mediator of the association between prenatal smoking exposure and ADHD symptoms at 6 years: the Hokkaido Study on Environment and Children's Health

Miyake, Kunio; Miyashita, Chihiro; Ikeda-Araki, Atsuko; Miura, Ryu; Itoh, Sachiko; Yamazaki, Keiko; Kobayashi, Sumitaka; Masuda, Hideyuki; Ooka, Tadao; Yamagata, Zentaro; Kishi, Reiko

DNA methylation of GFI1 as a mediator of the association between prenatal smoking exposure and ADHD symptoms at 6 years: the Hokkaido Study on Environment and Children's Health

Miyake, Kunio; Miyashita, Chihiro; Ikeda-Araki, Atsuko et al.

Clinical epigenetics, 2021, 13, 74

Permalink : https://hdl.handle.net/2115/81598

このアイテムのアクセス数:492件（2026-08-25 06:52 集計）

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アクセス権	open access
URI	https://hdl.handle.net/2115/81598
タイトル	DNA methylation of GFI1 as a mediator of the association between prenatal smoking exposure and ADHD symptoms at 6 years: the Hokkaido Study on Environment and Children's Health
著者	Miyake, Kunio ; Miyashita, Chihiro ; Ikeda-Araki, Atsuko ; Miura, Ryu ; Itoh, Sachiko ; Yamazaki, Keiko ; Kobayashi, Sumitaka ; Masuda, Hideyuki ; Ooka, Tadao ; Yamagata, Zentaro ; Kishi, Reiko
著者名 Miyake, Kunio
e-Rad_Researcher 70632389 著者名 Miyashita, Chihiro
著者名 Ikeda-Araki, Atsuko
著者名 Miura, Ryu
著者名 Itoh, Sachiko
著者名 Yamazaki, Keiko
著者名 Kobayashi, Sumitaka
著者名 Masuda, Hideyuki
著者名 Ooka, Tadao
著者名 Yamagata, Zentaro
e-Rad_Researcher 80112449 著者名 Kishi, Reiko
言語	英語
キーワード	ADHD
	Birth cohort
	DNA methylation
	DOHaD
	GFI1
	Prenatal smoking exposure
発行日	2021-04-07
出版者	BioMed Central
収録物名	Clinical epigenetics
巻(号)	13
ページ	74
抄録	BackgroundPrenatal smoking exposure has been associated with childhood attention-deficit/hyperactivity disorder (ADHD). However, the mechanism underlying this relationship remains unclear. We assessed whether DNA methylation differences may mediate the association between prenatal smoking exposure and ADHD symptoms at the age of 6 years.ResultsWe selected 1150 mother-infant pairs from the Hokkaido Study on the Environment and Children's Health. Mothers were categorized into three groups according to plasma cotinine levels at the third trimester: non-smokers (<= 0.21 ng/mL), passive smokers (0.21-11.48 ng/mL), and active smokers (>= 11.49 ng/mL). The children's ADHD symptoms were determined by the ADHD-Rating Scale at the age of 6 years. Maternal active smoking during pregnancy was significantly associated with an increased risk of ADHD symptoms (odds ratio, 1.89; 95% confidence interval, 1.14-3.15) compared to non-smoking after adjusting for covariates. DNA methylation of the growth factor-independent 1 transcriptional repressor (GFI1) region, as determined by bisulfite next-generation sequencing of cord blood samples, mediated 48.4% of the total effect of the association between maternal active smoking during pregnancy and ADHD symptoms. DNA methylation patterns of other genes (aryl-hydrocarbon receptor repressor [AHRR], cytochrome P450 family 1 subfamily A member 1 [CYP1A1], estrogen receptor 1 [ESR1], and myosin IG [MYO1G]) regions did not exert a statistically significant mediation effect.ConclusionsOur findings demonstrated that DNA methylation of GFI1 mediated the association between maternal active smoking during pregnancy and ADHD symptoms at the age of 6 years.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
PISSN	1868-7075
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1186/s13148-021-01063-z