Diet supplementation with cholic acid promotes intestinal epithelial proliferation in rats exposed to γ-radiation

Hagio, Masahito; Shimizu, Hidehisa; Joe, Ga-Hyun; Takatsuki, Manami; Shiwaku, Maiko; Xu, Hong; Lee, Ja-Young; Fujii, Nobuyuki; Fukiya, Satoru; Hara, Hiroshi; Yokota, Atsushi; Ishizuka, Satoshi

Diet supplementation with cholic acid promotes intestinal epithelial proliferation in rats exposed to γ-radiation

Hagio, Masahito; Shimizu, Hidehisa; Joe, Ga-Hyun et al.

Toxicology Letters, 2015, 232(1), 246-252

Permalink : https://hdl.handle.net/2115/81755

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アクセス権	open access
URI	https://hdl.handle.net/2115/81755
タイトル	Diet supplementation with cholic acid promotes intestinal epithelial proliferation in rats exposed to γ-radiation
著者	Hagio, Masahito ; Shimizu, Hidehisa ; Joe, Ga-Hyun ; Takatsuki, Manami ; Shiwaku, Maiko ; Xu, Hong ; Lee, Ja-Young ; Fujii, Nobuyuki ; Fukiya, Satoru ; Hara, Hiroshi ; Yokota, Atsushi ; Ishizuka, Satoshi
著者名 Hagio, Masahito
著者名 Shimizu, Hidehisa
著者名 Joe, Ga-Hyun
著者名 Takatsuki, Manami
著者名 Shiwaku, Maiko
著者名 Xu, Hong
著者名 Lee, Ja-Young
著者名 Fujii, Nobuyuki
e-Rad_Researcher 10370157 著者名 Fukiya, Satoru
e-Rad_Researcher 70198894 著者名 Hara, Hiroshi
e-Rad_Researcher 50220554 著者名 Yokota, Atsushi
e-Rad_Researcher 00271627 著者名 Ishizuka, Satoshi
言語	英語
キーワード	Bile acid
	Intestinal epithelial kinetics
	γ-rays
	Ultra performance liquid chromatography-electrospray ionization mass spectrometry
	Cecal contents
	IEC-6 cells
発行日	2015-01
出版者	Elsevier
収録物名	Toxicology Letters
巻(号)	232(1)
ページ	246-252
抄録	Consumption of a high-fat diet increases some secondary bile acids (BAs) such as deoxycholic acid (DCA) in feces. DCA is derived from cholic acid (CA), a primary BA. We evaluated intestinal epithelial proliferation and BA metabolism in response to oral administration of cholic acid (CA) in rats to determine the influence of a CA diet on the responses of gut epithelia to γ-rays. WKAH/HkmSlc rats were divided into two dietary groups: control diet or CA-supplemented (2 g/kg diet) diet. Some of the rats from each group were irradiated with γ-rays, and epithelial cell proliferation in the colon was analyzed histochemically. Unirradiated CA-fed rats had high levels of DCA and CA in the sera, as well as the presence of taurocholic acid in their feces. Significant increases were observed in both epithelial proliferation and the number of epithelial cells in the colon of the CA-fed rats, and this effect was observed at 8 weeks after γ-ray exposure. Furthermore, extracts from both cecal contents and sera of the unirradiated CA-fed rats promoted proliferation of IEC-6 cells. These results indicate that BAs in enterohepatic circulation promote proliferation and survival of the intestinal epithelium after receiving DNA damage.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
権利情報	© 2014. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
PISSN	0378-4274
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.toxlet.2014.10.011