Ingestion of difructose anhydride III partially suppresses the deconjugation and 7α-dehydroxylation of bile acids in rats fed with a cholic acid-supplemented diet

Lee, Dong Geun; Hori, Shota; Kohmoto, Ohji; Kitta, Shinri; Yoshida, Ryo; Tanaka, Yasutake; Shimizu, Hidehisa; Takahashi, Keisuke; Nagura, Taizo; Uchino, Hirokatsu; Fukiya, Satoru; Yokota, Atsushi; Ishizuka, Satoshi

Ingestion of difructose anhydride III partially suppresses the deconjugation and 7α-dehydroxylation of bile acids in rats fed with a cholic acid-supplemented diet

Lee, Dong Geun; Hori, Shota; Kohmoto, Ohji et al.

Bioscience, Biotechnology, and Biochemistry, 2019, 83(7), 1329-1335

Permalink : https://hdl.handle.net/2115/81807

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アクセス権	open access
URI	https://hdl.handle.net/2115/81807
タイトル	Ingestion of difructose anhydride III partially suppresses the deconjugation and 7α-dehydroxylation of bile acids in rats fed with a cholic acid-supplemented diet
著者	Lee, Dong Geun ; Hori, Shota ; Kohmoto, Ohji ; Kitta, Shinri ; Yoshida, Ryo ; Tanaka, Yasutake ; Shimizu, Hidehisa ; Takahashi, Keisuke ; Nagura, Taizo ; Uchino, Hirokatsu ; Fukiya, Satoru ; Yokota, Atsushi ; Ishizuka, Satoshi
著者名 Lee, Dong Geun
著者名 Hori, Shota
著者名 Kohmoto, Ohji
著者名 Kitta, Shinri
著者名 Yoshida, Ryo
著者名 Tanaka, Yasutake
著者名 Shimizu, Hidehisa
著者名 Takahashi, Keisuke
著者名 Nagura, Taizo
著者名 Uchino, Hirokatsu
e-Rad_Researcher 10370157 著者名 Fukiya, Satoru
e-Rad_Researcher 50220554 著者名 Yokota, Atsushi
e-Rad_Researcher 00271627 著者名 Ishizuka, Satoshi
言語	英語
キーワード	Difructose anhydride III
	bile acid
	deconjugation
	7α-dehydroxylation
発行日	2019-07
収録物名	Bioscience, Biotechnology, and Biochemistry
巻(号)	83(7)
ページ	1329-1335
抄録	Difructose anhydride III (DFAIII) is a prebiotic involved in the reduction of secondary bile acids (BAs). We investigated whether DFAIII modulates BA metabolism, including enterohepatic circulation, in the rats fed with a diet supplemented with cholic acid (CA), one of the 12αhydroxylated BAs. After acclimation, the rats were fed with a control diet or a diet supplemented with DFAIII. After 2 weeks, each group was further divided into two groups and was fed diet with or without CA supplementation at 0.5 g/kg diet. BA levels were analyzed in aortic and portal plasma, liver, intestinal content, and feces. As a result, DFAIII ingestion reduced the fecal deoxycholic acid level via the partial suppression of deconjugation and 7αdehydroxylation of BAs following CA supplementation. These results suggest that DFAIII suppresses production of deoxycholic acid in conditions of high concentrations of 12αhydroxylated BAs in enterohepatic circulation, such as obesity or excess energy intake.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	This is a pre-copyedited, author-produced version of an article accepted for publication in Bioscience biotechnology and biochemistry following peer review. The version of record Dong Geun Lee, Shota Hori, Ohji Kohmoto, Shinri Kitta, Ryo Yoshida, Yasutake Tanaka, Hidehisa Shimizu, Keisuke Takahashi, Taizo Nagura, Hirokatsu Uchino, Satoru Fukiya, Atsushi Yokota, Satoshi Ishizuka, Ingestion of difructose anhydride III partially suppresses the deconjugation and 7α-dehydroxylation of bile acids in rats fed with a cholic acid-supplemented diet, Bioscience, Biotechnology, and Biochemistry, Volume 83, Issue 7, 3 July 2019, Pages 1329-1335, is available online at: https://doi.org/10.1080/09168451.2019.1597617.
PISSN	0916-8451
EISSN	1347-6947
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1080/09168451.2019.1597617