Antibacterial Effect of Amino Acid-Silver Complex Loaded Montmorillonite Incorporated in Dental Acrylic Resin

Yoshihara, Kumiko; Nagaoka, Noriyuki; Umeno, Aya; Sonoda, Akinari; Obika, Hideki; Yoshida, Yasuhiro; Van Meerbeek, Bart; Makita, Yoji

Antibacterial Effect of Amino Acid-Silver Complex Loaded Montmorillonite Incorporated in Dental Acrylic Resin

Yoshihara, Kumiko; Nagaoka, Noriyuki; Umeno, Aya et al.

Materials, 2021, 14(6), 1442

Permalink : https://hdl.handle.net/2115/81909

このアイテムのアクセス数:526件（2026-08-24 20:15 集計）

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https://doi.org/10.3390/ma14061442			40

論文情報

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アクセス権	open access
URI	https://hdl.handle.net/2115/81909
タイトル	Antibacterial Effect of Amino Acid-Silver Complex Loaded Montmorillonite Incorporated in Dental Acrylic Resin
著者	Yoshihara, Kumiko ; Nagaoka, Noriyuki ; Umeno, Aya ; Sonoda, Akinari ; Obika, Hideki ; Yoshida, Yasuhiro ; Van Meerbeek, Bart ; Makita, Yoji
e-Rad_Researcher 90631581 著者名 Yoshihara, Kumiko
e-Rad_Researcher 70304326 著者名 Nagaoka, Noriyuki
著者名 Umeno, Aya
e-Rad_Researcher 90357335 著者名 Sonoda, Akinari
e-Rad_Researcher 90356741 著者名 Obika, Hideki
e-Rad_Researcher 90281162 著者名 Yoshida, Yasuhiro
著者名 Van Meerbeek, Bart
e-Rad_Researcher 80357988 著者名 Makita, Yoji
言語	英語
キーワード	montmorillonite
	amino acid
	antibacterial
	Streptococcus mutans
	nuclear magnetic resonance
	X-ray diffraction
発行日	2021-03
出版者	MDPI
収録物名	Materials
巻(号)	14(6)
ページ	1442
抄録	Several dental materials contain silver for antibacterial effect, however the effect is relatively low. The reason for the lower antibacterial efficacy of silver is considered to be the fact that silver ions bind to chloride ions in saliva. To develop new effective silver antibacterial agents that can be useful in the mouth, we synthesized two novel amino acid (methionine or histidine)-silver complexes (Met or His-Ag) loaded with montmorillonite (Mont) and analyzed their antibacterial efficacy. At first the complexes were characterized using nuclear magnetic resonance (NMR), and amino acid-Ag complex-loaded Mont (amino acid-Ag-Mont) were characterized using X-ray diffraction (XRD) and scanning electron microscopy (SEM). The antibacterial efficacy of these materials in dental acrylic resin was then investigated by bacterial growth measurement using a spectrophotometer. As controls, commercially available silver-loaded zeolite and silver-zirconium phosphate were also tested. Dental acrylic resin incorporating His-Ag-Mont strongly inhibited Streptococcus mutans growth. This was explained by the fact that His-Ag complex revealed the highest amounts of silver ions in the presence of chloride. The structure of the amino acid-Ag complexes affected the silver ion presence in chloride and the antibacterial efficacy. His-Ag-Mont might be used as antibacterial agents for dental materials.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
関連情報	PMID 33809621
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.3390/ma14061442