Long-term prognostic factors of patients with hepatocellular carcinoma who survive over 10 years after hepatectomy

Shimada, Shingo; Kamiyama, Toshiya; Orimo, Tatsuya; Nagatsu, Akihisa; Asahi, Yoh; Sakamoto, Yuzuru; Kamachi, Hirofumi; Taketomi, Akinobu

Long-term prognostic factors of patients with hepatocellular carcinoma who survive over 10 years after hepatectomy

Shimada, Shingo; Kamiyama, Toshiya; Orimo, Tatsuya et al.

Journal of Surgical Oncology, 2020, 121(8), 1209-1217

Permalink : https://hdl.handle.net/2115/81916

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アクセス権	open access
URI	https://hdl.handle.net/2115/81916
タイトル	Long-term prognostic factors of patients with hepatocellular carcinoma who survive over 10 years after hepatectomy
著者	Shimada, Shingo ; Kamiyama, Toshiya ; Orimo, Tatsuya ; Nagatsu, Akihisa ; Asahi, Yoh ; Sakamoto, Yuzuru ; Kamachi, Hirofumi ; Taketomi, Akinobu
e-Rad_Researcher 40755576 著者名 Shimada, Shingo
e-Rad_Researcher 80322816 著者名 Kamiyama, Toshiya
著者名 Orimo, Tatsuya
著者名 Nagatsu, Akihisa
著者名 Asahi, Yoh
著者名 Sakamoto, Yuzuru
e-Rad_Researcher 60374237 著者名 Kamachi, Hirofumi
e-Rad_Researcher 70363364 著者名 Taketomi, Akinobu
言語	英語
キーワード	hepatectomy
	hepatocellular carcinoma
	long-term prognoses
	nonviral hepatitis
	solitary intrahepatic recurrence
発行日	2020-06-15
出版者	John Wiley & Sons
収録物名	Journal of Surgical Oncology
巻(号)	121(8)
ページ	1209-1217
抄録	Background and Objectives The aim was to evaluate long-term prognostic factors in hepatocellular carcinoma (HCC) patients who survived over 10 years after hepatectomy and compare prognostic factors between patients with recurrence who died and survived 10 years after initial hepatectomy. Methods We analyzed the HCC patients without recurrence over 10 years after hepatectomy (n = 35), those with recurrence who survived over 10 years (n = 48), and those who died within 10 years (n = 132). Results The rate of recurrence was 16.3%, 10-year overall survival rate was 38.6%, and the 10-year recurrence-free survival (RFS) rate was 16.7%. Nonviral, solitary tumor, well differentiation, and without severe fibrosis were independent favorable factors for long-term RFS. High cholinesterase levels, small tumors and without portal vein invasion were independent favorable factors for long-term survival among patients with recurrence. Long-term survivors with recurrence showed significantly low early recurrence, extrahepatic recurrence, multiple intrahepatic recurrences. Conclusion Important factors for long-term prognoses in HCC patients were a solitary tumor, small tumors, and no advanced fibrosis. A treatment for nonviral hepatitis is needed to achieve long-term RFS. Even patients who relapse might survive long term if they have a late or solitary intrahepatic recurrence, nonsevere cirrhosis, and curative treatment at recurrence.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	This is the peer reviewed version of the following article: Shimada, S, Kamiyama, T, Orimo, T, et al. Long‐term prognostic factors of patients with hepatocellular carcinoma who survive over 10 years after hepatectomy. J Surg Oncol. 2020; 121: 1209-1217, which has been published in final form at https://doi.org/10.1002/jso.25910. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
PISSN	0022-4790
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1002/jso.25910