Primary pulmonary lymphoepithelioma-like carcinoma with positive expression of Epstein-Barr virus and PD-L1: A case report

Sasaki, Akihiro; Kato, Tatsuya; Ujiie, Hideki; Cho, Yasushi; Sato, Masaaki; Kaji, Mitsuhito

Primary pulmonary lymphoepithelioma-like carcinoma with positive expression of Epstein-Barr virus and PD-L1: A case report

Sasaki, Akihiro; Kato, Tatsuya; Ujiie, Hideki et al.

International journal of surgery case reports, 2021, 79, 431-435

Permalink : https://hdl.handle.net/2115/81921

このアイテムのアクセス数:593件（2026-10-12 00:13 集計）

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https://doi.org/10.1016/j.ijscr.2021.01.066			32

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アクセス権	open access
URI	https://hdl.handle.net/2115/81921
タイトル	Primary pulmonary lymphoepithelioma-like carcinoma with positive expression of Epstein-Barr virus and PD-L1: A case report
著者	Sasaki, Akihiro ; Kato, Tatsuya ; Ujiie, Hideki ; Cho, Yasushi ; Sato, Masaaki ; Kaji, Mitsuhito
著者名 Sasaki, Akihiro
著者名 Kato, Tatsuya
著者名 Ujiie, Hideki
著者名 Cho, Yasushi
著者名 Sato, Masaaki
著者名 Kaji, Mitsuhito
言語	英語
キーワード	Lymphoepithelioma-like carcinoma (LELC)
	Epstein-Barr virus (EBV)
	EBV encoded small RNA (EBER)
	In situ hybridization (ISH)
	Programmed death-ligand 1 (PD-L1)
	Case report
発行日	2021-02
出版者	Elsevier
収録物名	International journal of surgery case reports
巻(号)	79
ページ	431-435
抄録	INTRODUCTION AND IMPORTANCE: Pulmonary lymphoepithelioma-like carcinoma (LELC) is a rare type of non-small cell lung cancer (NSCLC) that is classified as a subtype of unclassified carcinoma by the WHO. LELC is usually associated with Epstein-Barr virus (EBV) infection. LELC has often been observed in Southeast Asia; however, it is extremely rare in Japan. CASE PRESENTATION: A 60-year-old Japanese woman presented with an abnormal shadow in the left lung on chest radiography. Chest computed tomography showed a nodule located between the lingular and basal anteromedial segments. A blood test suggested an existing EBV infection, and LELC was suspected preoperatively in the transbronchial lung biopsy. She underwent a lingular and basal bi-segmentectomy. The EBV-encoded small ribonucleic acid in-situ hybridization (EBER-ISH) was positive, and she was diagnosed with LELC. Moreover, programmed death-ligand 1 (PD-L1) expression was moderately positive. No recurrence was observed for 30 months. CLINICAL DISCUSSION: Although LELC has been reported as a low-grade malignancy with a good prognosis, the frequency of PD-Ll expression in LELC seems to be higher than that in other NSCLCs. Moreover, it has been reported that LELC patients with high PD-Ll expression are likely to have early recurrence/metastasis and poor prognosis. CONCLUSION: An investigation of PD-Ll expression for LELC would be useful considering the benefit of PD-1/PD-L1 blockade in patients with pulmonary LELC with high PD-Ll expression. The present case is the first report of LELC with positive expression of EBER-ISH and PD-Ll in Japan. (C) 2021 The Authors. Published by Elsevier Ltd on behalf of IJS Publishing Group Ltd.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution 4.0 International
PISSN	2210-2612
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1016/j.ijscr.2021.01.066