The response of adipose tissues to Mycoplasma pulmonis and Sendai virus infection in C57BL/6 and DBA/2 mice

Boonyarattanasoonthorn, Tussapon; Sato, Keisuke; Okamatsu-Ogura, Yuko; Morimatsu, Masami; Agui, Takashi

The response of adipose tissues to Mycoplasma pulmonis and Sendai virus infection in C57BL/6 and DBA/2 mice

Boonyarattanasoonthorn, Tussapon; Sato, Keisuke; Okamatsu-Ogura, Yuko et al.

Journal of veterinary medical science, 2021, 83(3), 403-411

Permalink : https://hdl.handle.net/2115/81957

このアイテムのアクセス数:455件（2026-10-15 17:55 集計）

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https://doi.org/10.1292/jvms.20-0625			20

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アクセス権	open access
URI	https://hdl.handle.net/2115/81957
タイトル	The response of adipose tissues to Mycoplasma pulmonis and Sendai virus infection in C57BL/6 and DBA/2 mice
著者	Boonyarattanasoonthorn, Tussapon ; Sato, Keisuke ; Okamatsu-Ogura, Yuko ; Morimatsu, Masami ; Agui, Takashi
著者名 Boonyarattanasoonthorn, Tussapon
著者名 Sato, Keisuke
e-Rad_Researcher 90527178 著者名 Okamatsu-Ogura, Yuko
e-Rad_Researcher 70241370 著者名 Morimatsu, Masami
e-Rad_Researcher 00212457 著者名 Agui, Takashi
言語	英語
キーワード	adipose tissue
	brown adipose tissue
	Mycoplasma pulmonis
	Sendai virus
	uncoupling protein 1
発行日	2021-03
出版者	公益社団法人日本獣医学会 (The Japanese Society of Veterinary Science)
収録物名	Journal of veterinary medical science
巻(号)	83(3)
ページ	403-411
抄録	Adipose tissues in mammals are categorized into white and brown adipose tissues in which cellular morphology, cell functions, and tissue distribution are different. White adipose tissue (WAT) plays a major role in energy reservation, while brown adipose tissue (BAT) mainly relates to the thermoregulation of the body. One interesting function of adipose tissue is the response to the infection, especially the pathogens that cause pneumonia. We have previously reported that DBA/2 (D2) mice are susceptible to pathogens causing pneumonia, Mycoplasma (M.) pulmonis and Sendai virus (SeV), whereas C57BL/6 (B6) mice are resistant to them. Furthermore, morphological alteration of mediastinal fat tissue (MFT) was seen after infection of M. pulmonis in D2 mice but not in B6 mice. In this study, we aimed to exhibit the difference in adipose tissue response in other areas, including interscapular brown adipose tissue (iBAT), inguinal white adipose tissue (ingWAT), and perigonadal WAT (perigoWAT) between resistant strain, B6 and susceptible strain, D2 after challenging them with M. pulmonis and SeV. Compared with B6 mice, D2 mice showed an increase in fat-associated lymphoid cluster in MFT, an increase in BAT in both iBAT and ingWAT after M. pulmonis and SeV infection. The results of this study indicate that pneumonia caused by M. pulmonis and SeV infection induces browning of adipocyte, suggesting that BAT plays a role in pathogen infection and inflammation.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
PISSN	0916-7250
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1292/jvms.20-0625