The enhancement of Th1 immune response by anti-PD-L1 antibody in cattle infected with Mycobacterium avium subsp. paratuberculosis

Sajiki, Yamato; Konnai, Satoru; Nagata, Reiko; Kawaji, Satoko; Nakamura, Hayato; Fujisawa, Sotaro; Okagawa, Tomohiro; Maekawa, Naoya; Kato, Yukinari; Suzuki, Yasuhiko; Murata, Shiro; Mori, Yasuyuki; Ohashi, Kazuhiko

The enhancement of Th1 immune response by anti-PD-L1 antibody in cattle infected with Mycobacterium avium subsp. paratuberculosis

Sajiki, Yamato; Konnai, Satoru; Nagata, Reiko et al.

Journal of veterinary medical science, 2021, 83(2), 162-166

Permalink : https://hdl.handle.net/2115/81959

このアイテムのアクセス数:468件（2026-08-19 12:46 集計）

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https://doi.org/10.1292/jvms.20-0590			15

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アクセス権	open access
URI	https://hdl.handle.net/2115/81959
タイトル	The enhancement of Th1 immune response by anti-PD-L1 antibody in cattle infected with Mycobacterium avium subsp. paratuberculosis
著者	Sajiki, Yamato ; Konnai, Satoru ; Nagata, Reiko ; Kawaji, Satoko ; Nakamura, Hayato ; Fujisawa, Sotaro ; Okagawa, Tomohiro ; Maekawa, Naoya ; Kato, Yukinari ; Suzuki, Yasuhiko ; Murata, Shiro ; Mori, Yasuyuki ; Ohashi, Kazuhiko
著者名 Sajiki, Yamato
e-Rad_Researcher 40396304 著者名 Konnai, Satoru
著者名 Nagata, Reiko
e-Rad_Researcher 30584388 著者名 Kawaji, Satoko
著者名 Nakamura, Hayato
著者名 Fujisawa, Sotaro
e-Rad_Researcher 80829036 著者名 Okagawa, Tomohiro
e-Rad_Researcher 70829035 著者名 Maekawa, Naoya
e-Rad_Researcher 00571811 著者名 Kato, Yukinari
e-Rad_Researcher 90206540 著者名 Suzuki, Yasuhiko
e-Rad_Researcher 10579163 著者名 Murata, Shiro
著者名 Mori, Yasuyuki
e-Rad_Researcher 90250498 著者名 Ohashi, Kazuhiko
言語	英語
キーワード	cattle
	immunotherapy
	Johne's disease
	programmed death-ligand 1
	Th1 response
発行日	2021-02
出版者	公益社団法人日本獣医学会 (The Japanese Society of Veterinary Science)
収録物名	Journal of veterinary medical science
巻(号)	83(2)
ページ	162-166
抄録	Johne's disease, caused by Mycobacterium avium subsp. paratuberculosis (MAP), is a chronic enteritis of ruminants. Previous studies have shown that programmed death-ligand 1 (PD-L1) is associated with the disease progression, and PD-L1 blockade activates MAP-specific Th1 responses in vitro. Here, we performed anti-PD-L1 antibody administration using 2 MAP-infected cattle at the late subclinical stage of infection. After administration, bacterial shedding was reduced or maintained at a low level. Additionally, MAP-specific Th1 cytokine production was upregulated, and CD69 expression was increased in T cells. Collectively, the treatment has a potential as a novel control method against Johne's disease.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
PISSN	0916-7250
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1292/jvms.20-0590