Redox-Sensitive Mapping of a Mouse Tumor Model Using Sparse Projection Sampling of Electron Paramagnetic Resonance

Kimura, Kota; Iguchi, Nami; Nakano, Hitomi; Yasui, Hironobu; Matsumoto, Shingo; Inanami, Osamu; Hirata, Hiroshi

Redox-Sensitive Mapping of a Mouse Tumor Model Using Sparse Projection Sampling of Electron Paramagnetic Resonance

Kimura, Kota; Iguchi, Nami; Nakano, Hitomi et al.

Antioxidants & redox signaling, 2021, 36(1-3), 69

Permalink : https://hdl.handle.net/2115/81997

このアイテムのアクセス数:517件（2026-10-12 02:16 集計）

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ファイル	フォーマット	サイズ	閲覧回数	説明
https://doi.org/10.1089/ars.2021.0003			23

論文情報

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アクセス権	open access
URI	https://hdl.handle.net/2115/81997
タイトル	Redox-Sensitive Mapping of a Mouse Tumor Model Using Sparse Projection Sampling of Electron Paramagnetic Resonance
著者	Kimura, Kota ; Iguchi, Nami ; Nakano, Hitomi ; Yasui, Hironobu ; Matsumoto, Shingo ; Inanami, Osamu ; Hirata, Hiroshi
著者名 Kimura, Kota
著者名 Iguchi, Nami
著者名 Nakano, Hitomi
e-Rad_Researcher 10570228 著者名 Yasui, Hironobu
e-Rad_Researcher 90741041 著者名 Matsumoto, Shingo
e-Rad_Researcher 10193559 著者名 Inanami, Osamu
e-Rad_Researcher 60250958 著者名 Hirata, Hiroshi
言語	英語
キーワード	redox-sensitive mapping
	electron paramagnetic resonance
	nitroxyl radical
	compressed sensing
	mouse xenograft model
発行日	2021-06-23
出版者	Mary Ann Liebert
収録物名	Antioxidants & redox signaling
巻(号)	36(1-3)
ページ	69
抄録	Aims: This work aimed to establish an accelerated imaging system for redox-sensitive mapping in a mouse tumor model using electron paramagnetic resonance (EPR) and nitroxyl radicals. Results: Sparse sampling of EPR spectral projections was demonstrated for a solution phantom. The reconstructed three-dimensional (3D) images with filtered back-projection (FBP) and compressed sensing image reconstruction were quantitatively assessed for the solution phantom. Mouse xenograft models of a human-derived pancreatic ductal adenocarcinoma cell line, MIA PaCa-2, were also measured for redox-sensitive mapping with the sparse sampling technique. Innovation: A short-lifetime redox-sensitive nitroxyl radical (N-15-labeled perdeuterated Tempone) could be measured to map the decay rates of the EPR signals for the mouse xenograft models. Acceleration of 3D EPR image acquisition broadened the choices of nitroxyl radical probes with various redox sensitivities to biological environments. Conclusion: Sparse sampling of EPR spectral projections accelerated image acquisition in the 3D redox-sensitive mapping of mouse tumor-bearing legs fourfold compared with conventional image acquisition with FBP.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
PISSN	1523-0864
NCID	AA11507484
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1089/ars.2021.0003