Determination of the cutoff values of Th2 markers for the prediction of future exacerbation in severe asthma: An analysis from the Hokkaido Severe Asthma Cohort Study

Kimura, Hirokazu; Makita, Hironi; Taniguchi, Natsuko; Takei, Nozomu; Matsumoto, Munehiro; Kimura, Hiroki; Goudarzi, Houman; Shimizu, Kaoruko; Suzuki, Masaru; Nishimura, Masaharu; Konno, Satoshi

Determination of the cutoff values of Th2 markers for the prediction of future exacerbation in severe asthma: An analysis from the Hokkaido Severe Asthma Cohort Study

Kimura, Hirokazu; Makita, Hironi; Taniguchi, Natsuko et al.

Allergology international, 2021, 70(1), 68-73

Permalink : https://hdl.handle.net/2115/82005

このアイテムのアクセス数:478件（2026-08-25 16:24 集計）

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https://doi.org/10.1016/j.alit.2020.09.001			21

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アクセス権	open access
URI	https://hdl.handle.net/2115/82005
タイトル	Determination of the cutoff values of Th2 markers for the prediction of future exacerbation in severe asthma: An analysis from the Hokkaido Severe Asthma Cohort Study
著者	Kimura, Hirokazu ; Makita, Hironi ; Taniguchi, Natsuko ; Takei, Nozomu ; Matsumoto, Munehiro ; Kimura, Hiroki ; Goudarzi, Houman ; Shimizu, Kaoruko ; Suzuki, Masaru ; Nishimura, Masaharu ; Konno, Satoshi
著者名 Kimura, Hirokazu
著者名 Makita, Hironi
著者名 Taniguchi, Natsuko
著者名 Takei, Nozomu
著者名 Matsumoto, Munehiro
著者名 Kimura, Hiroki
著者名 Goudarzi, Houman
著者名 Shimizu, Kaoruko
著者名 Suzuki, Masaru
著者名 Nishimura, Masaharu
e-Rad_Researcher 20399835 著者名 Konno, Satoshi
言語	英語
キーワード	Asthma
	Biomarkers
	Cutoff value
	Exacerbation
	Th2 features
発行日	2021-01
出版者	Japanese Society of Allergology
収録物名	Allergology international
巻(号)	70(1)
ページ	68-73
抄録	Background: We recently reported that severe asthma patients with frequent exacerbations showed high blood eosinophil counts (Eo) and fractions of exhaled nitric oxide (FeNO) compared with non-exacerbators. However, we did not determine exact cutoff values related to exacerbation. The aim of this study was to determine the cutoff values of Eo and FeNO that could be related to the exacerbation of severe asthma. We also aimed to confirm the clinical utility of Th2 markers related to exacerbation. Methods: This study included 105 severe asthma patients who completed a three-year follow-up of a severe asthma cohort study, including smokers. Three Th2 markers were selected, viz., Eo, FeNO, and positive atopic status. Regarding Eo and FeNO, we determined the cutoff values for the definition of "positive" Th2 features using receiver operating characteristic curve analyses, based on the comparisons between frequent exacerbators and other patients. Results: The cutoff values for positive Th2 features were Eo >= 250 cells/mL and FeNO >= 31 ppb. Sixteen patients (15.2%) had no Th2 features, 40 (38.1%) had one, 25 ( 23.8%) had two, and 24 (22.9%) had three. A high number of positive Th2 features was significantly associated with exacerbation frequencies over three years (p < 0.05). Similarly, compared to patients with one or no Th2 features, those with three Th2 features had a significantly higher probability of having more than one exacerbation (p < 0.05). Conclusions: The cutoff values determined in the current analysis were good predictors of future exacerbations in severe asthma patients. Copyright (C) 2020, Japanese Society of Allergology. Production and hosting by Elsevier B.V.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
PISSN	1323-8930
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1016/j.alit.2020.09.001