Immunological Responses to Seoul Orthohantavirus in Experimentally and Naturally Infected Brown Rats (Rattus norvegicus)

Yasuda, Shumpei P.; Shimizu, Kenta; Koma, Takaaki; Nguyen Thuy Hoa; Mai Quynh Le; Wei, Zhuoxing; Muthusinghe, Devinda S.; Lokupathirage, Sithumini M. W.; Hasebe, Futoshi; Yamashiro, Tetsu; Arikawa, Jiro; Yoshimatsu, Kumiko

Immunological Responses to Seoul Orthohantavirus in Experimentally and Naturally Infected Brown Rats (Rattus norvegicus)

Yasuda, Shumpei P.; Shimizu, Kenta; Koma, Takaaki et al.

Viruses-Basel, 2021, 13(4), 665

Permalink : https://hdl.handle.net/2115/82007

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アクセス権	open access
URI	https://hdl.handle.net/2115/82007
タイトル	Immunological Responses to Seoul Orthohantavirus in Experimentally and Naturally Infected Brown Rats (Rattus norvegicus)
著者	Yasuda, Shumpei P. ; Shimizu, Kenta ; Koma, Takaaki ; Nguyen Thuy Hoa ; Mai Quynh Le ; Wei, Zhuoxing ; Muthusinghe, Devinda S. ; Lokupathirage, Sithumini M. W. ; Hasebe, Futoshi ; Yamashiro, Tetsu ; Arikawa, Jiro ; Yoshimatsu, Kumiko
著者名 Yasuda, Shumpei P.
著者名 Shimizu, Kenta
著者名 Koma, Takaaki
著者名 Nguyen Thuy Hoa
著者名 Mai Quynh Le
著者名 Wei, Zhuoxing
著者名 Muthusinghe, Devinda S.
著者名 Lokupathirage, Sithumini M. W.
著者名 Hasebe, Futoshi
著者名 Yamashiro, Tetsu
著者名 Arikawa, Jiro
e-Rad_Researcher 90220722 著者名 Yoshimatsu, Kumiko
言語	英語
キーワード	hemorrhagic fever with renal syndrome
	bunyavirus
	IgM
	CTLs
	reservoir
発行日	2021-04
出版者	MDPI
収録物名	Viruses-Basel
巻(号)	13(4)
ページ	665
抄録	To clarify the mechanism of Seoul orthohantavirus (SEOV) persistence, we compared the humoral and cell-mediated immune responses to SEOV in experimentally and naturally infected brown rats. Rats that were experimentally infected by the intraperitoneal route showed transient immunoglobulin M (IgM) production, followed by an increased anti-SEOV immunoglobulin G (IgG) antibody response and maturation of IgG avidity. The level of SEOV-specific cytotoxic T lymphocytes (CTLs) peaked at 6 days after inoculation and the viral genome disappeared from serum. In contrast, naturally infected brown rats simultaneously had a high rate of SEOV-specific IgM and IgG antibodies (28/43). Most of the IgM-positive rats (24/27) had the SEOV genome in their lungs, suggesting that chronic SEOV infection was established in those rats. In female rats with IgG avidity maturation, the viral load in the lungs was decreased. On the other hand, there was no relationship between IgG avidity and viral load in the lungs in male rats. A CTL response was not detected in naturally infected rats. The difference between immune responses in the experimentally and naturally infected rats is associated with the establishment of chronic infection in natural hosts.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.3390/v13040665