Chronic low-dose exposure to imidacloprid potentiates high fat diet-mediated liver steatosis in C57BL/6J male mice

Nimako, Collins; Ikenaka, Yoshinori; Okamatsu-Ogura, Yuko; Bariuan, Jussiaea V; Kobayashi, Atsushi; Yamazaki, Ryo; Taira, Kumiko; Hoshi, Nobuhiko; Hirano, Tetsushi; Nakayama, Shouta M. M.; Ishizuka, Mayumi

Chronic low-dose exposure to imidacloprid potentiates high fat diet-mediated liver steatosis in C57BL/6J male mice

Nimako, Collins; Ikenaka, Yoshinori; Okamatsu-Ogura, Yuko et al.

Journal of veterinary medical science, 2021, 83(3), 487-500

Permalink : https://hdl.handle.net/2115/82023

このアイテムのアクセス数:531件（2026-08-13 10:14 集計）

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https://doi.org/10.1292/jvms.20-0479			12

論文情報

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アクセス権	open access
URI	https://hdl.handle.net/2115/82023
タイトル	Chronic low-dose exposure to imidacloprid potentiates high fat diet-mediated liver steatosis in C57BL/6J male mice
著者	Nimako, Collins ; Ikenaka, Yoshinori ; Okamatsu-Ogura, Yuko ; Bariuan, Jussiaea V ; Kobayashi, Atsushi ; Yamazaki, Ryo ; Taira, Kumiko ; Hoshi, Nobuhiko ; Hirano, Tetsushi ; Nakayama, Shouta M. M. ; Ishizuka, Mayumi
著者名 Nimako, Collins
e-Rad_Researcher 40543509 著者名 Ikenaka, Yoshinori
e-Rad_Researcher 90527178 著者名 Okamatsu-Ogura, Yuko
著者名 Bariuan, Jussiaea V
著者名 Kobayashi, Atsushi
著者名 Yamazaki, Ryo
著者名 Taira, Kumiko
著者名 Hoshi, Nobuhiko
著者名 Hirano, Tetsushi
e-Rad_Researcher 90647629 著者名 Nakayama, Shouta M. M.
e-Rad_Researcher 50332474 著者名 Ishizuka, Mayumi
言語	英語
キーワード	neonicotinoid insecticides
	imidacloprid
	liver steatosis
	no observable adverse effect level (NOAEL)
発行日	2021-03
出版者	公益社団法人日本獣医学会 (The Japanese Society of Veterinary Science)
収録物名	Journal of veterinary medical science
巻(号)	83(3)
ページ	487-500
抄録	Hepatic steatosis is known to precede a continuum of events that lead to hepatic metabolic dysfunction, inflammation and carcinogenesis. Recently, studies have linked xenobiotic exposures to hepatic steatogenesis and its associated metabolic disorders; however, the underlying mechanisms remain elusive. This study aimed to elucidate the mechanistic role of imidacloprid in the prevalence of high fat diet (HFD)-induced liver steatosis, using a C57BL/6J mice model. Mice (3 weeks old) were fed with HFD and treated with 0.6 mg/kg bw/day (one-tenth of the NOAEL) of imidacloprid through water or diet, for 24 weeks. In a controlled group, mice were fed with only HFD. At the end of the study, imidacloprid treatment significantly potentiated HFD-induced body weight gain in mice. Also, imidacloprid increased the liver weights of mice, with complimentary reductions in mesenteric and gonadal white adipose tissue weights. Histopathological analysis of liver revealed a drastic steatosis in imidacloprid treated mice. Following a real-time qPCR analysis, imidacloprid upregulated transcriptions of hepatic fatty acid biosynthesis-related transcription factors and genes. Imidacloprid also induced hepatic expression of the gene encoding pregnane X receptor; but had no significant effect on hepatic expressions of liver X receptor and aryl hydrocarbon receptor. The imidacloprid treatment further enhanced serum alanine aminotransferase levels but downregulated hepatic antioxidant mRNA expressions. Ultimately, this study suggested an imidacloprid-potentiation effects on prevalence of HFD-induced liver steatosis via transcriptional modulations of the hepatic FA biosynthesis pathway.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
PISSN	0916-7250
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1292/jvms.20-0479