Serologic and molecular evidence for circulation of Crimean-Congo hemorrhagic fever virus in ticks and cattle in Zambia

Kajihara, Masahiro; Simuunza, Martin; Saasa, Ngonda et al.

PLoS neglected tropical diseases, 2021, 15(6), e0009452

Permalink : https://hdl.handle.net/2115/82227

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https://doi.org/10.1371/journal.pntd.0009452     19

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アクセス権
open access
URI
https://hdl.handle.net/2115/82227
タイトル
Serologic and molecular evidence for circulation of Crimean-Congo hemorrhagic fever virus in ticks and cattle in Zambia
著者
Kajihara, Masahiro ; Simuunza, Martin ; Saasa, Ngonda ; Dautu, George ; Mori-Kajihara, Akina ; Qiu, Yongjin ; Nakao, Ryo ; Eto, Yoshiki ; Furumoto, Hayato ; Hang'ombe, Bernard M. ; Orba, Yasuko ; Sawa, Hirofumi ; Simulundu, Edgar ; Fukushi, Shuetsu ; Morikawa, Shigeru ; Saijo, Masayuki ; Arikawa, Jiro ; Kabilika, Swithine ; Monze, Mwaka ; Mukonka, Victor ; Mweene, Aaron ; Takada, Ayato ; Yoshimatsu, Kumiko
著者名
Kajihara, Masahiro
著者名
Simuunza, Martin
著者名
Saasa, Ngonda
著者名
Dautu, George
著者名
Mori-Kajihara, Akina
著者名
Qiu, Yongjin
著者名
Nakao, Ryo
著者名
Eto, Yoshiki
著者名
Furumoto, Hayato
著者名
Hang'ombe, Bernard M.
著者名
Orba, Yasuko
著者名
Sawa, Hirofumi
著者名
Simulundu, Edgar
著者名
Fukushi, Shuetsu
著者名
Morikawa, Shigeru
著者名
Saijo, Masayuki
著者名
Arikawa, Jiro
著者名
Kabilika, Swithine
著者名
Monze, Mwaka
著者名
Mukonka, Victor
著者名
Mweene, Aaron
著者名
Takada, Ayato
e-Rad_Researcher
90220722
著者名
Yoshimatsu, Kumiko
言語
英語
発行日
2021-06
出版者
PLOS
収録物名
PLoS neglected tropical diseases
巻(号)
15(6)
ページ
e0009452
抄録
Author summary Crimean-Congo hemorrhagic fever (CCHF) is a severe viral disease mainly transmitted by ticks. Effective prophylactics and therapeutics have not been established for this disease yet. While CCHF is endemic in Africa, information on the distribution and genetic diversity of CCHF virus (CCHFV) is quite limited in many Sub-Saharan African countries. In this study, we conducted serologic and molecular epidemiologic investigations for CCHFV infection in cattle and ticks in Zambia. Serologic screening revealed that 8.4% of cattle were tested positive for CCHFV-specific IgG. Hyalomma ticks infected with CCHFV were also identified by genetic screening. Phylogenetic analyses showed that one of the CCHFVs detected in Zambia was a genetic reassortant between African and Asian CCHFV strains. Currently, Zambia is considered CCHF-free country because CCHF cases have never been reported. However, the findings in this study indicate that CCHFV is maintained in Hyalomma ticks and occasionally transmitted to vertebrate hosts such as cattle in Zambia. Further epidemiologic studies and continuous monitoring of CCHFV infection should be implemented in the southern African region. Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne zoonosis with a high case fatality rate in humans. Although the disease is widely found in Africa, Europe, and Asia, the distribution and genetic diversity of CCHF virus (CCHFV) are poorly understood in African countries. To assess the risks of CCHF in Zambia, where CCHF has never been reported, epidemiologic studies in cattle and ticks were conducted. Through an indirect immunofluorescence assay, CCHFV nucleoprotein-specific serum IgG was detected in 8.4% (88/1,047) of cattle. Among 290 Hyalomma ticks, the principal vector of CCHFV, the viral genome was detected in 11 ticks. Phylogenetic analyses of the CCHFV S and M genome segments revealed that one of the detected viruses was a genetic reassortant between African and Asian strains. This study provides compelling evidence for the presence of CCHFV in Zambia and its transmission to vertebrate hosts.
資源タイプ
学術雑誌論文
出版タイプ
Version of Record
PISSN
1935-2735
関連情報 (isIdenticalTo)
出版社版DOI
https://doi.org/10.1371/journal.pntd.0009452