open access

https://hdl.handle.net/2115/82349

Nonsteroidal anti-inflammatory drugs use in patients with chronic kidney disease are often prescribed from different clinicians than those who diagnosed them

英語

pharmacoepidemiology

2020-08

John Wiley & Sons

Pharmacoepidemiology and drug safety

29(8)

873-880

Purpose When prescribing nonsteroidal anti-inflammatory drugs (NSAIDs) for chronic kidney disease (CKD), patients' pathology and concomitant medications should be considered. In our pharmaceutical experience, NSAIDs are often prescribed by departments that are different from those that diagnosed CKD. That is, NSAIDs may be prescribed for patients without the advice of the clinicians who diagnosed them. In this study, we aimed to elucidate how frequently such cases occur. Methods We used the large health insurance claims database constructed by JMDC Inc., Tokyo. We evaluated the proportions of CKD diagnosis and NSAID prescription by different clinical departments and institutions. Results A total of 224 014 out-patients were included in the analysis; they were divided into CKD (n = 1501) and non-CKD groups (n = 222 513). The internal medicine departments diagnosed CKD most frequently (74.8% of the patients) and surgical departments rarely diagnosed CKD. However, the proportion of prescribed NSAIDs was high in other departments, especially surgical departments. In the CKD group, 50.4% of the patients received CKD diagnosis and NSAID prescription from different clinical departments; 72.8% of the patients received a diagnosis and prescription from different medical institutions. Conclusion Our study revealed that NSAIDs are often prescribed to patients with CKD from different clinicians than those who diagnosed them.

学術雑誌論文

Accepted Manuscript

This is the peer reviewed version of the following article: Imai, S, Momo, K, Kashiwagi, H, Miyai, T, Sugawara, M, Takekuma, Y. Nonsteroidal anti‐inflammatory drugs use in patients with chronic kidney disease are often prescribed from different clinicians than those who diagnosed them. Pharmacoepidemiol Drug Saf. 2020; 29: 873– 880, which has been published in final form at https://doi.org/10.1002/pds.5027. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.

1053-8569