Thymoquinone and Curcumin Defeat Aging-Associated Oxidative Alterations Induced by D-Galactose in Rats' Brain and Heart

El-Far, Ali H.; Elewa, Yaser H. A.; Abdelfattah, Elsayeda-Zeinab A. et al.

International Journal of Molecular Sciences, 2021, 22(13), 6839

Permalink : https://hdl.handle.net/2115/82385

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アクセス権
open access
URI
https://hdl.handle.net/2115/82385
タイトル
Thymoquinone and Curcumin Defeat Aging-Associated Oxidative Alterations Induced by D-Galactose in Rats' Brain and Heart
著者
El-Far, Ali H. ; Elewa, Yaser H. A. ; Abdelfattah, Elsayeda-Zeinab A. ; Alsenosy, Abdel-Wahab A. ; Atta, Mustafa S. ; Abou-Zeid, Khalid M. ; Al Jaouni, Soad K. ; Mousa, Shaker A. ; Noreldin, Ahmed E.
著者名
El-Far, Ali H.
著者名
Elewa, Yaser H. A.
著者名
Abdelfattah, Elsayeda-Zeinab A.
著者名
Alsenosy, Abdel-Wahab A.
著者名
Atta, Mustafa S.
著者名
Abou-Zeid, Khalid M.
著者名
Al Jaouni, Soad K.
著者名
Mousa, Shaker A.
著者名
Noreldin, Ahmed E.
言語
英語
キーワード
thymoquinone
curcumin
D-galactose
oxidative stress
anti-aging
発行日
2021-07-01
出版者
MDPI
収録物名
International Journal of Molecular Sciences
巻(号)
22(13)
ページ
6839
抄録
D-galactose (D-gal) administration causes oxidative disorder and is widely utilized in aging animal models. Therefore, we subcutaneously injected D-gal at 200 mg/kg BW dose to assess the potential preventive effect of thymoquinone (TQ) and curcumin (Cur) against the oxidative alterations induced by D-gal. Other than the control, vehicle, and D-gal groups, the TQ and Cur treated groups were orally supplemented at 20 mg/kg BW of each alone or combined. TQ and Cur effectively suppressed the oxidative alterations induced by D-gal in brain and heart tissues. The TQ and Cur combination significantly decreased the elevated necrosis in the brain and heart by D-gal. It significantly reduced brain caspase 3, calbindin, and calcium-binding adapter molecule 1 (IBA1), heart caspase 3, and BCL2. Expression of mRNA of the brain and heart TP53, p21, Bax, and CASP-3 were significantly downregulated in the TQ and Cur combination group along with upregulation of BCL2 in comparison with the D-gal group. Data suggested that the TQ and Cur combination is a promising approach in aging prevention.
資源タイプ
学術雑誌論文
出版タイプ
Version of Record
PISSN
1422-0067
関連情報 (isIdenticalTo)
出版社版DOI
https://doi.org/10.3390/ijms22136839