Serological Evidence of Filovirus Infection in Nonhuman Primates in Zambia

Changula, Katendi; Simulundu, Edgar; Lombe, Boniface Pongombo; Nakayama, Eri; Miyamoto, Hiroko; Takahashi, Yuji; Sawa, Hirofumi; Simukonda, Chuma; Hang'ombe, Bernard M.; Takada, Ayato

Serological Evidence of Filovirus Infection in Nonhuman Primates in Zambia

Changula, Katendi; Simulundu, Edgar; Lombe, Boniface Pongombo et al.

Viruses-Basel, 2021, 13(7), 1283

Permalink : https://hdl.handle.net/2115/82512

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論文情報

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アクセス権	open access
URI	https://hdl.handle.net/2115/82512
タイトル	Serological Evidence of Filovirus Infection in Nonhuman Primates in Zambia
著者	Changula, Katendi ; Simulundu, Edgar ; Lombe, Boniface Pongombo ; Nakayama, Eri ; Miyamoto, Hiroko ; Takahashi, Yuji ; Sawa, Hirofumi ; Simukonda, Chuma ; Hang'ombe, Bernard M. ; Takada, Ayato
著者名 Changula, Katendi
著者名 Simulundu, Edgar
著者名 Lombe, Boniface Pongombo
著者名 Nakayama, Eri
著者名 Miyamoto, Hiroko
著者名 Takahashi, Yuji
e-Rad_Researcher 30292006 著者名 Sawa, Hirofumi
著者名 Simukonda, Chuma
著者名 Hang'ombe, Bernard M.
e-Rad_Researcher 10292062 著者名 Takada, Ayato
言語	英語
キーワード	Ebola virus
	ebolavirus
	Marburg virus
	marburgvirus
	filovirus
	nonhuman primate
	antibody
	seroprevalence
	Zambia
発行日	2021-07
出版者	MDPI
収録物名	Viruses-Basel
巻(号)	13(7)
ページ	1283
抄録	Ebolaviruses and marburgviruses are filoviruses that are known to cause severe hemorrhagic fever in humans and nonhuman primates (NHPs). While some bat species are suspected to be natural reservoirs of these filoviruses, wild NHPs often act as intermediate hosts for viral transmission to humans. Using an enzyme-linked immunosorbent assay, we screened two NHP species, wild baboons and vervet monkeys captured in Zambia, for their serum IgG antibodies specific to the envelope glycoproteins of filoviruses. From 243 samples tested, 39 NHPs (16%) were found to be seropositive either for ebolaviruses or marburgviruses with endpoint antibody titers ranging from 100 to 25,600. Interestingly, antibodies reactive to Reston virus, which is found only in Asia, were detected in both NHP species. There was a significant difference in the seropositivity for the marburgvirus antigen between the two NHP species, with baboons having a higher positive rate. These results suggest that wild NHPs in Zambia might be nonlethally exposed to these filoviruses, and this emphasizes the need for continuous monitoring of filovirus infection in wild animals to better understand the ecology of filoviruses and to assess potential risks of outbreaks in humans in previously nonendemic countries.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
EISSN	1999-4915
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.3390/v13071283