Acute exposure to environmentally relevant lead levels induces oxidative stress and neurobehavioral alterations in larval zebrafish (Danio rerio)

Kataba, Andrew; Botha, Tarryn L.; Nakayama, Shouta M. M.; Yohannes, Yared B.; Ikenaka, Yoshinori; Wepener, Victor; Ishizuka, Mayumi

Acute exposure to environmentally relevant lead levels induces oxidative stress and neurobehavioral alterations in larval zebrafish (Danio rerio)

Kataba, Andrew; Botha, Tarryn L.; Nakayama, Shouta M. M. et al.

Aquatic toxicology, 2020, 227, 105607

Permalink : https://hdl.handle.net/2115/82513

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アクセス権	open access
URI	https://hdl.handle.net/2115/82513
タイトル	Acute exposure to environmentally relevant lead levels induces oxidative stress and neurobehavioral alterations in larval zebrafish (Danio rerio)
著者	Kataba, Andrew ; Botha, Tarryn L. ; Nakayama, Shouta M. M. ; Yohannes, Yared B. ; Ikenaka, Yoshinori ; Wepener, Victor ; Ishizuka, Mayumi
著者名 Kataba, Andrew
著者名 Botha, Tarryn L.
著者名 Nakayama, Shouta M. M.
著者名 Yohannes, Yared B.
e-Rad_Researcher 40543509 著者名 Ikenaka, Yoshinori
著者名 Wepener, Victor
e-Rad_Researcher 50332474 著者名 Ishizuka, Mayumi
言語	英語
キーワード	Lead
	Zebrafish larvae
	Behavioral toxicology
	Hormesis
	Hyperactivity
発行日	2020-08-19
出版者	Elsevier
収録物名	Aquatic toxicology
巻(号)	227
ページ	105607
抄録	The ubiquitous contamination of environmental lead (Pb) remains a worldwide threat. Improper Pb mine waste disposal from an abandoned lead-zinc mine has recently unearthed widespread Pb poisoning in children in Kabwe Zambia. Although the adverse effects of Pb on human health have begun to receive attention, the ecotoxicological effects on aquatic vertebrates still need further investigation. In addition, there is paucity in the knowledge on the behavioural and molecular subcellular responses in larval zebrafish exposed to Pb within the range of environmental relevant concentration (average 3 mu g/L with maximum of 94 mu g/L) on aquatic organisms such as zebrafish. The adverse effects of environmentally relevant levels of Pb on larval zebrafish was evaluated by measuring swimming behaviour under alternating dark and light conditions. Larval zebrafish acutely exposed to environmentally relevant Pb exhibited neuro-behavioural alteration including enhanced hyperactivity under light conditions evidenced by increased distanced covered and speed compared to the control. The alteration of entire behavioral profiles was further associated with the disturbed expression patterns of mRNA level of key genes associated with antioxidant (HO-1, Ucp-2 and CoxI), proapoptotic gene (TP53), and antiapoptotic gene (Bcl-2). To our knowledge, this is the first report on the effects of environmentally relevant Pb levels from Kabwe, Zambia and their adverse neurobehavioural effects and subcellular molecular oxidative responses in larval zebrafish acutely exposed within a 30 min period. The current results would be beneficial in our understanding of the effects of low Pb levels acutely discharged into an aquatic environment and the life of aquatic organisms.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
権利情報	©2020. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
PISSN	0166-445X
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.aquatox.2020.105607