Minocycline prevents primary duck neurons from duck Tembusu virus-induced death

Kulprasertsri, Sittinee; Aoshima, Keisuke; Kobayashi, Atsushi et al.

Journal of veterinary medical science, 2021, 83(4), 734-741

Permalink : https://hdl.handle.net/2115/82671

このアイテムのアクセス数:513件（2026-08-14 00:48 集計）

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https://doi.org/10.1292/jvms.20-0735     18

論文情報

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アクセス権
open access
URI
https://hdl.handle.net/2115/82671
タイトル
Minocycline prevents primary duck neurons from duck Tembusu virus-induced death
著者
Kulprasertsri, Sittinee ; Aoshima, Keisuke ; Kobayashi, Atsushi ; Kimura, Takashi
著者名
Kulprasertsri, Sittinee
著者名
Aoshima, Keisuke
著者名
Kobayashi, Atsushi
e-Rad_Researcher
90261338
著者名
Kimura, Takashi
言語
英語
キーワード
bird
duck Tembusu virus
minocycline
neuroprotective effect
primary duck neuron
発行日
2021-04-24
出版者
公益社団法人 日本獣医学会 (The Japanese Society of Veterinary Science)
収録物名
Journal of veterinary medical science
巻(号)
83(4)
ページ
734-741
抄録
Duck Tembusu virus (DTMUV), a neurotropic flavivirus, is a causative agent of severe neurological diseases in different birds. No approved vaccines or antiviral therapeutic treatments are available to date. The poultry industry experiences significant economic losses due to DTMUV infections. Minocycline is a second- generation semi-synthetic tetracycline analogue that is commonly used as an antimicrobial treatment. Experimental studies have indicated the successful protective effects of minocycline against neuronal cell death from neurodegenerative diseases and viral encephalitis. The aim of this study was to investigate the effects of minocycline on DTMUV infection in neurons. Primary duck neurons were treated with minocycline, which exhibited neuroprotective effects via anti-apoptotic function rather than through viral replication inhibition. Minocycline might serve as a potential effective drug in DTMUV infection.
資源タイプ
学術雑誌論文
出版タイプ
Version of Record
PISSN
0916-7250
関連情報 (isIdenticalTo)
出版社版DOI
https://doi.org/10.1292/jvms.20-0735