Immune Thrombocytopenia Treated with Intravenous Erythromycin

Ohe, Masashi; Furuya, Ken; Goudarzi, Houman

Gazi Medical Journal, 2021, 32(4), 577-579

Permalink : https://hdl.handle.net/2115/82681

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アクセス権
open access
URI
https://hdl.handle.net/2115/82681
タイトル
Immune Thrombocytopenia Treated with Intravenous Erythromycin
著者
Ohe, Masashi ; Furuya, Ken ; Goudarzi, Houman
著者名
Ohe, Masashi
著者名
Furuya, Ken
e-Rad_Researcher
40713607
著者名
Goudarzi, Houman
言語
英語
キーワード
Immune thrombocytopenia
clarithromycin
erythromycin
prednisolone
bioavailability
発行日
2021-09-09
出版者
Gazi University
収録物名
Gazi Medical Journal
巻(号)
32(4)
ページ
577-579
抄録
Macrolides (MACs) such as clarithromycin (CAM) and erythromycin (EM) have immunomodulatory effects as well as anti-bacterial activity. In consideration of immunomodulatory effects, we report a patient with primary immune thrombocytopenia (ITP) treated with corticosteroids (CSs) combined with MACs. An 84-year-old woman with ITP was admitted to our hospital for further examination of reduced platelet counts. After admission, the patient was diagnosed with exacerbated primary ITP. The patient was successfully treated with intravenous immunoglobulin. However, the patient was unsuccessfully treated with CSs (i.e., prednisolone (PSL)and methyl PSL) combined with CAM. Eltrombopag (ELT), a thrombopoietin-receptor agonist, was successfully added. However, the patient suffered from aspiration pneumonia, making it impossible to administer oral drugs (i.e., PSL, CAM, and ELT). Alternatively, she was successfully treated with intravenous PSL combined with intravenous EM. This case shows that the efficacy of intravenous EM treatment may be higher than that of oral CAM treatment.
資源タイプ
学術雑誌論文
出版タイプ
Version of Record
EISSN
2147-2092
関連情報 (isIdenticalTo)
出版社版DOI
https://doi.org/10.12996/gmj.2021.129