Glucokinase is required for high-starch diet-induced beta-cell mass expansion in mice

Tsuchida, Kazuhisa; Nakamura, Akinobu; Miyoshi, Hideaki et al.

Journal of diabetes investigation, 2021, 12(9), 1545-1554

Permalink : https://hdl.handle.net/2115/82778

このアイテムのアクセス数:508件（2026-10-15 10:31 集計）

閲覧可能ファイル 

ファイル フォーマット サイズ 閲覧回数 説明
https://doi.org/10.1111/jdi.13532     49

論文情報

ファイル出力 EndNote Basic出力 Mendeley出力

アクセス権
open access
URI
https://hdl.handle.net/2115/82778
タイトル
Glucokinase is required for high-starch diet-induced beta-cell mass expansion in mice
著者
Tsuchida, Kazuhisa ; Nakamura, Akinobu ; Miyoshi, Hideaki ; Yang, Kelaier ; Yamauchi, Yuki ; Kawata, Shinichiro ; Omori, Kazuno ; Takahashi, Kiyohiko ; Kitao, Naoyuki ; Nomoto, Hiroshi ; Kameda, Hiraku ; Cho, Kyu Yong ; Seino, Yusuke ; Terauchi, Yasuo ; Atsumi, Tatsuya
著者名
Tsuchida, Kazuhisa
e-Rad_Researcher
70552420
著者名
Nakamura, Akinobu
著者名
Miyoshi, Hideaki
著者名
Yang, Kelaier
著者名
Yamauchi, Yuki
著者名
Kawata, Shinichiro
著者名
Omori, Kazuno
著者名
Takahashi, Kiyohiko
著者名
Kitao, Naoyuki
著者名
Nomoto, Hiroshi
著者名
Kameda, Hiraku
著者名
Cho, Kyu Yong
著者名
Seino, Yusuke
著者名
Terauchi, Yasuo
著者名
Atsumi, Tatsuya
言語
英語
キーワード
β-Cell mass
Glucokinase
High-starch diet
発行日
2021-09
出版者
John Wiley & Sons
収録物名
Journal of diabetes investigation
巻(号)
12(9)
ページ
1545-1554
抄録
Aims/Introduction We aimed to determine whether glucokinase is required for beta-cell mass expansion induced by high-starch diet (HSTD)-feeding, as has been shown in its high-fat diet-induced expansion. Materials and Methods Eight-week-old male wild-type (Gck(+/+)) or glucokinase haploinsufficient (Gck(+/-)) mice were fed either a normal chow (NC) or an HSTD for 15 weeks. The bodyweight, glucose tolerance, insulin sensitivity, insulin secretion and beta-cell mass were assessed. Results Both HSTD-fed Gck(+/+) and Gck(+/-) mice had significantly higher bodyweight than NC-fed mice. Insulin and oral glucose tolerance tests revealed that HSTD feeding did not affect insulin sensitivity nor glucose tolerance in either the Gck(+/+) or Gck(+/-) mice. However, during the oral glucose tolerance test, the 15-min plasma insulin concentration after glucose loading was significantly higher in the HSTD group than that in the NC group for Gck(+/+), but not for Gck(+/-) mice. beta-Cell mass was significantly larger in HSTD-fed Gck(+/+) mice than that in NC-fed Gck(+/+) mice. In contrast, the beta-cell mass of the HSTD-fed Gck(+/-) mice was not different from that of the NC-fed Gck(+/-) mice. Conclusions The results showed that HSTD feeding would increase pancreatic beta-cell mass and insulin secretion in Gck(+/+), but not Gck(+/-) mice. This observation implies that glucokinase in beta-cells would be required for the increase in beta-cell mass induced by HSTD feeding.
資源タイプ
学術雑誌論文
出版タイプ
Version of Record
PISSN
2040-1116
関連情報 (isIdenticalTo)
出版社版DOI
https://doi.org/10.1111/jdi.13532