Hepatectomy Combined with Diaphragmatic Resection for Hepatocellular Carcinoma with Diaphragmatic Involvement : A Propensity Score-Matched Analysis

Orimo, Tatsuya; Kamiyama, Toshiya; Wakayama, Kenji; Shimada, Shingo; Nagatsu, Akihisa; Asahi, Yoh; Sakamoto, Yuzuru; Kamachi, Hirofumi; Taketomi, Akinobu

Hepatectomy Combined with Diaphragmatic Resection for Hepatocellular Carcinoma with Diaphragmatic Involvement : A Propensity Score-Matched Analysis

Orimo, Tatsuya; Kamiyama, Toshiya; Wakayama, Kenji et al.

Annals of surgical oncology, 2020, 27, 4153-4163

Permalink : https://hdl.handle.net/2115/82886

このアイテムのアクセス数:581件（2026-08-19 21:17 集計）

閲覧可能ファイル

ファイル	フォーマット	サイズ	閲覧回数	説明
Ann Surg Oncol 2020 Jun 25	pdf	600 KB	462

論文情報

ファイル出力 EndNote Basic出力 Mendeley出力

アクセス権	open access
URI	https://hdl.handle.net/2115/82886
タイトル	Hepatectomy Combined with Diaphragmatic Resection for Hepatocellular Carcinoma with Diaphragmatic Involvement : A Propensity Score-Matched Analysis
著者	Orimo, Tatsuya ; Kamiyama, Toshiya ; Wakayama, Kenji ; Shimada, Shingo ; Nagatsu, Akihisa ; Asahi, Yoh ; Sakamoto, Yuzuru ; Kamachi, Hirofumi ; Taketomi, Akinobu
e-Rad_Researcher 80711861 著者名 Orimo, Tatsuya
e-Rad_Researcher 80322816 著者名 Kamiyama, Toshiya
e-Rad_Researcher 50646544 著者名 Wakayama, Kenji
e-Rad_Researcher 40755576 著者名 Shimada, Shingo
著者名 Nagatsu, Akihisa
著者名 Asahi, Yoh
著者名 Sakamoto, Yuzuru
e-Rad_Researcher 60374237 著者名 Kamachi, Hirofumi
e-Rad_Researcher 70363364 著者名 Taketomi, Akinobu
言語	英語
発行日	2020-10
出版者	Springer
収録物名	Annals of surgical oncology
巻(号)	27
ページ	4153-4163
抄録	Purpose We evaluated the short- and long-term surgical outcomes of hepatectomy combined with diaphragmatic resection for hepatocellular carcinoma (HCC) with diaphragmatic involvement. Methods We retrospectively reviewed the surgical outcomes of HCC patients with diaphragmatic resection (DR group) and HCC patients without diaphragmatic resection (non-DR group). We applied 1:1 propensity score matching (PSM) to these subjects. Results The study included 46 patients in DR group and 828 patients in non-DR group. The DR group cases were pathologically more advanced, and both overall and relapse-free survival among the patients in this group with pathological diaphragmatic invasion were similar to cases with pathological diaphragmatic fibrous adhesion. There were 40 patients from each group subjected to PSM. In these matched cohorts, there was no statistically significant difference between the two groups regarding perioperative outcomes, overall survival, and relapse-free survival. Multivariate analyses of our matched HCC patients revealed that alpha-fetoprotein expression and tumor size were independent prognostic factors for overall survival and poor differentiation for relapse-free survival, whereas neither diaphragmatic invasion nor diaphragmatic resection were prognostic indicators. The most frequent site of recurrence in non-DR group was the liver, whereas the most frequent site of recurrence in DR group was the lung before and after PSM. Conclusions The short- and long-term surgical outcomes of DR HCC cases are equivalent to their non-DR counterparts under a matched clinicopathological background. Hepatectomy combined with DR is an acceptable treatment for HCC with either diaphragmatic fibrous adhesion or diaphragmatic invasion.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	This is a post-peer-review, pre-copyedit version of an article published in Annals of surgical oncology. The final authenticated version is available online at: http://dx.doi.org/10.1245/s10434-020-08754-6
PISSN	1068-9265
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1245/s10434-020-08754-6