Spatiotemporal histological changes observed in mouse subcutaneous tissues during the foreign body reaction to silicone

Oe, Sao; Masum, Md. Abdul; Ichii, Osamu; Nishimura, Takanori; Nakamura, Teppei; Namba, Takashi; Otani, Yuki; Nakayama, Yasuhide; Elewa, Yaser Hosny Ali; Kon, Yasuhiro

Spatiotemporal histological changes observed in mouse subcutaneous tissues during the foreign body reaction to silicone

Oe, Sao; Masum, Md. Abdul; Ichii, Osamu et al.

Journal of biomedical materials research part A, 2020, 109(7), 1220-1231

Permalink : https://hdl.handle.net/2115/82900

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アクセス権	open access
URI	https://hdl.handle.net/2115/82900
タイトル	Spatiotemporal histological changes observed in mouse subcutaneous tissues during the foreign body reaction to silicone
著者	Oe, Sao ; Masum, Md. Abdul ; Ichii, Osamu ; Nishimura, Takanori ; Nakamura, Teppei ; Namba, Takashi ; Otani, Yuki ; Nakayama, Yasuhide ; Elewa, Yaser Hosny Ali ; Kon, Yasuhiro
著者名 Oe, Sao
著者名 Masum, Md. Abdul
e-Rad_Researcher 60547769 著者名 Ichii, Osamu
著者名 Nishimura, Takanori
著者名 Nakamura, Teppei
著者名 Namba, Takashi
著者名 Otani, Yuki
著者名 Nakayama, Yasuhide
著者名 Elewa, Yaser Hosny Ali
e-Rad_Researcher 10178402 著者名 Kon, Yasuhiro
言語	英語
キーワード	fibrosis
	foreign body reaction
	inflammation
	neutrophil extracellular traps
	silicone
発行日	2020-10-05
出版者	John Wiley & Sons
収録物名	Journal of biomedical materials research part A
巻(号)	109(7)
ページ	1220-1231
抄録	We investigated spatiotemporal changes in host tissues during foreign body reactions. Silicone tube was subcutaneously embedded into ICR mice, and tissue surrounding silicone (TSS) was observed at 2, 7, 14, 21, 28, 43, and 70 days (D) postsurgery. The thin layer (TL) and loose connective tissues (LCTs) (inside and outside the TSS) developed until D21 and densified afterward. Neutrophils infiltrated the TSS until D14 and formed neutrophil extracellular traps (NETs) in the TL during D7-21. In the LCTs, mast cell counts increased until D21, and macrophage numbers peaked at D14. Several macrophages showed LYVE-1 expression, supporting a tissue-remodeling role. Developmental indices of collagen fibers (CFs) and reticular fibers (RFs) increased during D2-21. NETs, but not neutrophils, were detected after D28. Mast cell numbers peaked at D43 and were maintained until D70. Myofibroblasts consistently localized to the TL from D14. During D21-28, the area of connective tissue (CNT), and CFs and RFs decreased and increased, respectively, and both remained constant during D28-70. The CF density remained constant from D21 and increased at D70. Thus, TSS showed two phases: inflammation and CNT development (D2-21), and inflammation convergence and CNT stabilization (D28-70). These results provide insights into foreign body reactions in clinical cases.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	This is the peer reviewed version of the following article: https://onlinelibrary.wiley.com/doi/full/10.1002/jbm.a.37115, which has been published in final form at https://doi.org/10.1002/jbm.a.37115. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
PISSN	1549-3296
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1002/jbm.a.37115