Bone Tissue Regeneration by Collagen Scaffolds with Different Calcium Phosphate Coatings: Amorphous Calcium Phosphate and Low-Crystalline Apatite

Santhakumar, Syama; Oyane, Ayako; Nakamura, Maki; Yoshino, Yuto; Alruwaili, Mohammed Katib; Miyaji, Hirofumi

Bone Tissue Regeneration by Collagen Scaffolds with Different Calcium Phosphate Coatings: Amorphous Calcium Phosphate and Low-Crystalline Apatite

Santhakumar, Syama; Oyane, Ayako; Nakamura, Maki et al.

Materials, 2021, 14(19), 5860

Permalink : https://hdl.handle.net/2115/82915

このアイテムのアクセス数:525件（2026-08-09 19:04 集計）

閲覧可能ファイル

ファイル	フォーマット	サイズ	閲覧回数	説明
2021 Syama Materials	pdf	2.05 MB	375

論文情報

ファイル出力 EndNote Basic出力 Mendeley出力

アクセス権	open access
URI	https://hdl.handle.net/2115/82915
タイトル	Bone Tissue Regeneration by Collagen Scaffolds with Different Calcium Phosphate Coatings: Amorphous Calcium Phosphate and Low-Crystalline Apatite
著者	Santhakumar, Syama ; Oyane, Ayako ; Nakamura, Maki ; Yoshino, Yuto ; Alruwaili, Mohammed Katib ; Miyaji, Hirofumi
著者名 Santhakumar, Syama
e-Rad_Researcher 50356672 著者名 Oyane, Ayako
e-Rad_Researcher 00568925 著者名 Nakamura, Maki
著者名 Yoshino, Yuto
著者名 Alruwaili, Mohammed Katib
e-Rad_Researcher 50372256 著者名 Miyaji, Hirofumi
言語	英語
キーワード	apatite
	amorphous calcium phosphate (ACP)
	bone tissue engineering
	scaffolds
	mineralization
発行日	2021-10-07
出版者	MDPI
収録物名	Materials
巻(号)	14(19)
ページ	5860
抄録	Surface-mineralized collagen sponges have attracted much attention as scaffolds for bone tissue engineering. Recently, we developed amorphous calcium phosphate (ACP) and low-crystalline apatite coating processes on collagen sponges. In the present study, we applied these coating processes to granular collagen sponges (referred to as Col) to compare the bone tissue regeneration capabilities of ACP-coated and apatite-coated Col (referred to as Col-ACP and Col-Ap, respectively) using a rat cranial bone defect model. According to micro-CT and histological analyses, Col-Ap enhanced bone tissue regeneration compared to Col, whereas Col-ACP did not. These results not only demonstrated the superior bone tissue regeneration capability of Col-Ap, but also indicated limitations of the in vitro simulated body fluid (SBF) test used in our previous study. Despite the apatite-forming ability of Col-ACP in SBF, it was ineffective in improving bone tissue regeneration in vivo, unlike Col-Ap, most likely due to the quick resorption of the ACP coating in the defect site. The present results clarified the importance of the coating stability in vivo and revealed that the low-crystalline apatite coating was more beneficial than the ACP coating in the fabrication of surface-mineralized collagen sponges for use as bone tissue engineering scaffolds.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution 4.0 International
PISSN	1996-1944
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.3390/ma14195860