Comprehensive lipidomic profiling in serum and multiple tissues from a mouse model of diabetes

Chen, Zhen; Liang, Qiangrong; Wu, Yue; Gao, Zijun; Kobayashi, Satoru; Patel, Joy; Li, Cairong; Cai, Fei; Zhang, Youhua; Liang, Chongsheng; Chiba, Hitoshi; Hui, Shu-Ping

Comprehensive lipidomic profiling in serum and multiple tissues from a mouse model of diabetes

Chen, Zhen; Liang, Qiangrong; Wu, Yue et al.

Metabolomics, 2020, 16(11), 115

Permalink : https://hdl.handle.net/2115/82948

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論文情報

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アクセス権	open access
URI	https://hdl.handle.net/2115/82948
タイトル	Comprehensive lipidomic profiling in serum and multiple tissues from a mouse model of diabetes
著者	Chen, Zhen ; Liang, Qiangrong ; Wu, Yue ; Gao, Zijun ; Kobayashi, Satoru ; Patel, Joy ; Li, Cairong ; Cai, Fei ; Zhang, Youhua ; Liang, Chongsheng ; Chiba, Hitoshi ; Hui, Shu-Ping
e-Rad_Researcher 60802634 著者名 Chen, Zhen
著者名 Liang, Qiangrong
著者名 Wu, Yue
著者名 Gao, Zijun
著者名 Kobayashi, Satoru
著者名 Patel, Joy
著者名 Li, Cairong
著者名 Cai, Fei
著者名 Zhang, Youhua
著者名 Liang, Chongsheng
e-Rad_Researcher 70197622 著者名 Chiba, Hitoshi
e-Rad_Researcher 90337030 著者名 Hui, Shu-Ping
言語	英語
キーワード	Lipidomics
	Type 2 diabetes mellitus
	Mouse model
	Multiple tissues
	Lipid hydroperoxides
	Oxidative stress
発行日	2020-10-16
出版者	Springer
収録物名	Metabolomics
巻(号)	16(11)
ページ	115
抄録	Introduction Diabetes mellitus is a serious metabolic disorder causing multiple organ damage in human. However, the lipidomic profiles in different organs and their associations are rarely studied in either diabetic patients or animals. Objectives To evaluate and compare the characteristics of lipid species in serum and multiple tissues in a diabetic mouse model. Methods Semi-quantitative profiling analyses of intact and oxidized lipids were performed in serum and multiple tissues from a diabetic mouse model fed a high fat diet and treated with streptozotocin by using LC/HRMS and MS/MS. The total content of each lipid class, and the tissue-specific lipid species in all tissue samples were determined and compared by multivariate analyses. Results The diabetic mouse model displayed characteristic differences in serum and multiple organs: the brain and heart showed the largest reduction in cardiolipin, while the kidney had more alterations in triacylglycerol. Interestingly, the lipidomic differences also existed between different regions of the same organ: cardiolipin species with highly polyunsaturated fatty acyls decreased only in atrium but not in ventricle, while renal cortex showed longer fatty acyl chains for both increased and decreased triacylglycerol species than renal medulla. Importantly, diabetes caused an accumulation of lipid hydroperoxides, suggesting that oxidative stress was induced in all organs except for the brain during the development of diabetes. Conclusions These findings provided novel insight into the organ-specific relationship between diabetes and lipid metabolism, which might be useful for evaluating not only diabetic tissue injury but also the effectiveness of diabetic treatments.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	This is a post-peer-review, pre-copyedit version of an article published in Metabolomics. The final authenticated version is available online at: https://doi.org/10.1007/s11306-020-01732-9
PISSN	1573-3882
EISSN	1573-3890
関連情報	PMID 33067714
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1007/s11306-020-01732-9