Chitin-Based Double-Network Hydrogel as Potential Superficial Soft-Tissue-Repairing Materials

Huang, Junchao; Frauenlob, Martin; Shibata, Yuki; Wang, Lei; Nakajima, Tasuku; Nonoyama, Takayuki; Tsuda, Masumi; Tanaka, Shinya; Kurokawa, Takayuki; Gong, Jian Ping

Chitin-Based Double-Network Hydrogel as Potential Superficial Soft-Tissue-Repairing Materials

Huang, Junchao; Frauenlob, Martin; Shibata, Yuki et al.

Biomacromolecules, 2020, 21(10), 4220-4230

Permalink : https://hdl.handle.net/2115/82976

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アクセス権	open access
URI	https://hdl.handle.net/2115/82976
タイトル	Chitin-Based Double-Network Hydrogel as Potential Superficial Soft-Tissue-Repairing Materials
著者	Huang, Junchao ; Frauenlob, Martin ; Shibata, Yuki ; Wang, Lei ; Nakajima, Tasuku ; Nonoyama, Takayuki ; Tsuda, Masumi ; Tanaka, Shinya ; Kurokawa, Takayuki ; Gong, Jian Ping
著者名 Huang, Junchao
著者名 Frauenlob, Martin
著者名 Shibata, Yuki
e-Rad_Researcher 70637975 著者名 Wang, Lei
e-Rad_Researcher 80574350 著者名 Nakajima, Tasuku
e-Rad_Researcher 50709251 著者名 Nonoyama, Takayuki
e-Rad_Researcher 30431307 著者名 Tsuda, Masumi
e-Rad_Researcher 70261287 著者名 Tanaka, Shinya
e-Rad_Researcher 40451439 著者名 Kurokawa, Takayuki
e-Rad_Researcher 20250417 著者名 Gong, Jian Ping
言語	英語
キーワード	Chitin
	double-network hydrogel
	modulus
	strength
	toughness
	tissue repairing materials
発行日	2020-10-12
出版者	American Chemical Society(ACS)
収録物名	Biomacromolecules
巻(号)	21(10)
ページ	4220-4230
抄録	Chitin is a biopolymer, which has been proven to be a biomedical material candidate, yet the weak mechanical properties seriously limit their potentials. In this work, a chitin-based double-network (DN) hydrogel has been designed as a potential superficial repairing material. The hydrogel was synthesized through a double-network (DN) strategy composing hybrid regenerated chitin nanofiber (RCN)-poly (ethylene glycol diglycidyl ether) (PEGDE) as the first network and polyacrylamide (PAAm) as the second network. The hybrid RCN-PEGDE/PAAm DN hydrogel was strong and tough, possessing Young’s modulus (elasticity) E 0.097 ± 0.020 MPa, fracture stress σf 0.449 ± 0.025 MPa, and work of fracture Wf 5.75 ± 0.35 MJ·m–3. The obtained DN hydrogel was strong enough for surgical requirements in the usage of soft tissue scaffolds. In addition, chitin endowed the DN hydrogel with good bacterial resistance and accelerated fibroblast proliferation, which increased the NIH3T3 cell number by nearly five times within 3 days. Subcutaneous implantation studies showed that the DN hydrogel did not induce inflammation after 4 weeks, suggesting a good biosafety in vivo. These results indicated that the hybrid RCN-PEGDE/PAAm DN hydrogel had great prospect as a rapid soft-tissue-repairing material.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	This document is the Accepted Manuscript version of a Published Work that appeared in final form in Biomacromolecules, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.biomac.0c01003.
PISSN	1525-7797
NCID	AA11435474
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1021/acs.biomac.0c01003