Genomic profiling of intestinal/mixed-type superficial non-ampullary duodenal epithelial tumors

Miyamoto, Shuichi; Suda, Goki; Ishikawa, Marin et al.

JGH open, 2021, 5(9), 1071-1077

Permalink : https://hdl.handle.net/2115/82978

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https://doi.org/10.1002/jgh3.12632     42

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アクセス権
open access
URI
https://hdl.handle.net/2115/82978
タイトル
Genomic profiling of intestinal/mixed-type superficial non-ampullary duodenal epithelial tumors
著者
Miyamoto, Shuichi ; Suda, Goki ; Ishikawa, Marin ; Hayashi, Hideyuki ; Nimura, Satoshi ; Matsuno, Yoshihiro ; Mori, Ryo ; Tanishima, Shigeki ; Kudo, Takahiko ; Takagi, Tomofumi ; Yamamoto, Yoshiya ; Ono, Shoko ; Shimizu, Yuichi ; Sakamoto, Naoya
著者名
Miyamoto, Shuichi
e-Rad_Researcher
20447460
著者名
Suda, Goki
著者名
Ishikawa, Marin
著者名
Hayashi, Hideyuki
著者名
Nimura, Satoshi
著者名
Matsuno, Yoshihiro
著者名
Mori, Ryo
著者名
Tanishima, Shigeki
著者名
Kudo, Takahiko
著者名
Takagi, Tomofumi
著者名
Yamamoto, Yoshiya
著者名
Ono, Shoko
著者名
Shimizu, Yuichi
e-Rad_Researcher
10334418
著者名
Sakamoto, Naoya
言語
英語
キーワード
duodenal cancer
genomic testing
next-generation sequencing
superficial non-ampullary duodenal epithelial tumor
発行日
2021-09
出版者
John Wiley & Sons
収録物名
JGH open
巻(号)
5(9)
ページ
1071-1077
抄録
Background and Aim: The mechanism underlying carcinogenesis and the genomic features of superficial non-ampullary duodenal epithelial tumors (SNADETs) have not been elucidated in detail. In this study, we examined the genomic features of incipient SNADETs, such as small lesions resected via endoscopic treatment, using next-generation sequencing (NGS). Methods: Twenty consecutive patients who underwent endoscopic treatment for SNADETs of less than 20 mm between January and December 2017 were enrolled. Targeted genomic sequencing was performed through NGS using a panel of 160 cancer-related genes. Furthermore, the alteration/mutation frequencies in SNADETs were examined. Results: The maximum size of the SNADETs examined in this study was 12 mm in diameter. Five SNADETs were classified as low-grade dysplasia (LGD) tumors, while 14 SNADETs were classified as high-grade dysplasia tumors. Only one carcinoma in situ was detected. NGS data for 16 samples were obtained. APC alterations were detected in 81% of samples (13/16). KRAS, BRAF, and TP53 alterations were detected in 25% (4/16), 18.8% (3/16), and 6.3% (1/16) of cases, respectively. Conclusion: We detected APC alterations in most small SNADETs resected via endoscopic treatment, from LGD to carcinoma samples. Even in SNADETs classified as small LGD exhibited KRAS and BRAF alterations.
資源タイプ
学術雑誌論文
出版タイプ
Version of Record
PISSN
2397-9070
関連情報 (isIdenticalTo)
出版社版DOI
https://doi.org/10.1002/jgh3.12632