Acromegaly Cases Exhibiting Increased Growth Hormone Levels during Oral Glucose Loading with Preadministration of Dipeptidyl Peptidase-4 Inhibitor

Oba-Yamamoto, Chiho; Kameda, Hiraku; Miyoshi, Hideaki; Sekizaki, Tomonori; Takase, Takahiro; Yanagimachi, Tsuyoshi; Fujita, Yukihiro; Nomoto, Hiroshi; Cho, Kyu Yong; Nakamura, Akinobu; Nagai, So; Atsumi, Tatsuya

Acromegaly Cases Exhibiting Increased Growth Hormone Levels during Oral Glucose Loading with Preadministration of Dipeptidyl Peptidase-4 Inhibitor

Oba-Yamamoto, Chiho; Kameda, Hiraku; Miyoshi, Hideaki et al.

Internal medicine, 2021, 60(15), 2375-2383

Permalink : https://hdl.handle.net/2115/83015

このアイテムのアクセス数:453件（2026-08-25 06:03 集計）

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https://doi.org/10.2169/internalmedicine.4755-20			29

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アクセス権	open access
URI	https://hdl.handle.net/2115/83015
タイトル	Acromegaly Cases Exhibiting Increased Growth Hormone Levels during Oral Glucose Loading with Preadministration of Dipeptidyl Peptidase-4 Inhibitor
著者	Oba-Yamamoto, Chiho ; Kameda, Hiraku ; Miyoshi, Hideaki ; Sekizaki, Tomonori ; Takase, Takahiro ; Yanagimachi, Tsuyoshi ; Fujita, Yukihiro ; Nomoto, Hiroshi ; Cho, Kyu Yong ; Nakamura, Akinobu ; Nagai, So ; Atsumi, Tatsuya
著者名 Oba-Yamamoto, Chiho
e-Rad_Researcher 20826127 著者名 Kameda, Hiraku
著者名 Miyoshi, Hideaki
著者名 Sekizaki, Tomonori
著者名 Takase, Takahiro
著者名 Yanagimachi, Tsuyoshi
著者名 Fujita, Yukihiro
著者名 Nomoto, Hiroshi
著者名 Cho, Kyu Yong
著者名 Nakamura, Akinobu
著者名 Nagai, So
e-Rad_Researcher 20301905 著者名 Atsumi, Tatsuya
言語	英語
キーワード	acromegaly
	growth hormone
	glucose-dependent insulinotropic polypeptide
発行日	2021-08-01
出版者	日本内科学会(The Japanese Society of Internal Medicine)
収録物名	Internal medicine
巻(号)	60(15)
ページ	2375-2383
抄録	Objective Glucose-dependent insulinotropic polypeptide (GIP) is speculated to worsen growth hormone (GH) hypersecretion in acromegaly and to be a cause of paradoxical increases in GH (PI-GH) during 75-g oral glucose tolerance testing (75-g OGTT). Dipeptidyl peptidase-4 inhibitors (DPP4is), which increase the circulating concentration of active GIP, are frequently administered to diabetic patients, including those with acromegaly. We aimed to determine whether or not the administration of a DPP4i increases GH concentration, especially in patients demonstrating PI-GH during a DPP4i-OGTT, in which a DPP4i was administered immediately before 75-g OGTT. Methods This prospective cross-sectional study was carried out on acromegalic patients admitted to Hokkaido University hospital between June 2011 and May 2018. The participants underwent both 75-g OGTT and DPP4i-OGTT. For those who underwent surgery, immunohistochemical staining and quantitative polymerase chain reaction (PCR) for the GIP receptor (GIPR) were performed on the resected pituitary adenomas. Results Twenty-five percent of the participants had PI-GH confirmed (3 of 12 cases). Two of the three participants who demonstrated PI-GH exhibited higher circulating GH concentrations during DPP4i-OGTT than during OGTT. The increase in plasma glucose was reduced during DPP4i-OGTT compared to during 75-g OGTT, suggesting that the increase in GH during DPP4i-OGTT was due not to high glucose concentrations but instead increased GIP caused by the administration of DPP4i. The adenoma from one participant with PI-GH displayed positive immunostaining for GIPR and a higher GIPR messenger ribonucleic acid (mRNA) expression than the others. Conclusion DPP4i may enhance the GH secretion response during glucose loading, especially in individuals with PI-GH.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
PISSN	0918-2918
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.2169/internalmedicine.4755-20