Genistein Directly Represses the Phosphorylation of STAT5 in Lactating Mammary Epithelial Cells

Tsugami, Yusaku; Wakasa, Haruka; Nishimura, Takanori et al.

ACS Omega, 2021, 6(35), 22765-22772

Permalink : https://hdl.handle.net/2115/83069

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https://doi.org/10.1021/acsomega.1c03107     23

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アクセス権
open access
URI
https://hdl.handle.net/2115/83069
タイトル
Genistein Directly Represses the Phosphorylation of STAT5 in Lactating Mammary Epithelial Cells
著者
Tsugami, Yusaku ; Wakasa, Haruka ; Nishimura, Takanori ; Kobayashi, Ken
著者名
Tsugami, Yusaku
著者名
Wakasa, Haruka
e-Rad_Researcher
10237729
著者名
Nishimura, Takanori
e-Rad_Researcher
30449003
著者名
Kobayashi, Ken
言語
英語
発行日
2021-09-07
出版者
American Chemical Society
収録物名
ACS Omega
巻(号)
6(35)
ページ
22765-22772
抄録
Genistein is a soy isoflavone and shows various physiological activities, such as affinities for estrogen receptors (ERs) and inhibitory effects on the epidermal growth factor receptor (EGFR) pathway. A previous study reported that genistein downregulates milk production ability in mammary epithelial cells (MECs) while decreasing the phosphorylation of STAT5. The ER and EGFR pathways indirectly regulate STAT5. In this study, the repressing mechanism of genistein against the phosphorylation of STAT5 was investigated using a culture model of mouse MECs with milk production ability. The results revealed that genistein did not influence the behavior of ERa and ER beta, whereas genistein immediately repressed the phosphorylation of ERK1/2. However, the decrease in phosphorylated STAT5 occurred independent of the phosphorylation of EGFR. Genistein repressed new phosphorylation of STAT5 by prolactin without influencing the phosphorylation of JAK2. In conclusion, this study indicates that genistein directly inhibits the phosphorylation of STAT5 in lactating MECs.
資源タイプ
学術雑誌論文
出版タイプ
Version of Record
PISSN
2470-1343
関連情報 (isIdenticalTo)
出版社版DOI
https://doi.org/10.1021/acsomega.1c03107