Correlation of active contact location with weight gain after subthalamic nucleus deep brain stimulation: a case series

Eguchi, Katsuki; Shirai, Shinichi; Matsushima, Masaaki et al.

BMC neurology, 2021, 21(1), 351

Permalink : https://hdl.handle.net/2115/83166

このアイテムのアクセス数:490件（2026-08-17 02:06 集計）

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https://doi.org/10.1186/s12883-021-02383-6     10

論文情報

ファイル出力 EndNote Basic出力 Mendeley出力

アクセス権
open access
URI
https://hdl.handle.net/2115/83166
タイトル
Correlation of active contact location with weight gain after subthalamic nucleus deep brain stimulation: a case series
著者
Eguchi, Katsuki ; Shirai, Shinichi ; Matsushima, Masaaki ; Kano, Takahiro ; Yamazaki, Kazuyoshi ; Hamauchi, Shuji ; Sasamori, Toru ; Seki, Toshitaka ; Hirata, Kenji ; Kitagawa, Mayumi ; Otsuki, Mika ; Shiga, Tohru ; Houkin, Kiyohiro ; Sasaki, Hidenao ; Yabe, Ichiro
著者名
Eguchi, Katsuki
著者名
Shirai, Shinichi
ORCID
0000-0001-6585-3686
著者名
Matsushima, Masaaki
e-Rad_Researcher
20374324
著者名
Kano, Takahiro
e-Rad_Researcher
10883275
著者名
Yamazaki, Kazuyoshi
著者名
Hamauchi, Shuji
e-Rad_Researcher
40746848
著者名
Sasamori, Toru
著者名
Seki, Toshitaka
e-Rad_Researcher
30431365
著者名
Hirata, Kenji
著者名
Kitagawa, Mayumi
e-Rad_Researcher
10372880
著者名
Otsuki, Mika
e-Rad_Researcher
80374495
著者名
Shiga, Tohru
e-Rad_Researcher
90229146
著者名
Houkin, Kiyohiro
e-Rad_Researcher
80281806
著者名
Sasaki, Hidenao
e-Rad_Researcher
60372273
著者名
Yabe, Ichiro
言語
英語
キーワード
Deep brain stimulation
Parkinson's disease
Subthalamic nucleus
Weight gain
発行日
2021-09-13
出版者
BioMed Central
収録物名
BMC neurology
巻(号)
21(1)
ページ
351
抄録
Background Weight gain (WG) is a frequently reported side effect of subthalamic deep brain stimulation; however, the underlying mechanisms remain unclear. The active contact locations influence the clinical outcomes of subthalamic deep brain stimulation, but it is unclear whether WG is directly associated with the active contact locations. We aimed to determine whether WG is associated with the subthalamic deep brain stimulation active contact locations. Methods We enrolled 14 patients with Parkinson's disease who underwent bilateral subthalamic deep brain stimulation between 2013 and 2019. Bodyweight and body mass index were measured before and one year following the surgery. The Lead-DBS Matlab toolbox was used to determine the active contact locations based on magnetic resonance imaging and computed tomography. We also created sweet spot maps for WG using voxel-wise statistics, based on volume of tissue activation and the WG of each patient. Fluorodeoxyglucose-positron emission tomography data were also acquired before and one year following surgery, and statistical parametric mapping was used to evaluate changes in brain metabolism. We examined which brain regions' metabolism fluctuation significantly correlated with increased body mass index scores and positron emission tomography data. Results One year after surgery, the body mass index increase was 2.03 kg/m(2). The sweet spots for WG were bilateral, mainly located dorsally outside of the subthalamic nucleus (STN). Furthermore, WG was correlated with increased metabolism in the left limbic and associative regions, including the middle temporal gyrus, inferior frontal gyrus, and orbital gyrus. Conclusions Although the mechanisms underlying WG following subthalamic deep brain stimulation are possibly multifactorial, our findings suggest that dorsal stimulation outside of STN may lead to WG. The metabolic changes in limbic and associative cortical regions after STN-DBS may also be one of the mechanisms underlying WG. Further studies are warranted to confirm whether dorsal stimulation outside of STN changes the activities of these cortical regions.
資源タイプ
学術雑誌論文
出版タイプ
Version of Record
関連情報 (isIdenticalTo)
出版社版DOI
https://doi.org/10.1186/s12883-021-02383-6