A novel nairovirus associated with acute febrile illness in Hokkaido, Japan

Kodama, Fumihiro; Yamaguchi, Hiroki; Park, Eunsil; Tatemoto, Kango; Sashika, Mariko; Nakao, Ryo; Terauchi, Yurino; Mizuma, Keita; Orba, Yasuko; Kariwa, Hiroaki; Hagiwara, Katsuro; Okazaki, Katsunori; Goto, Akiko; Komagome, Rika; Miyoshi, Masahiro; Ito, Takuya; Yamano, Kimiaki; Yoshii, Kentaro; Funaki, Chiaki; Ishizuka, Mariko; Shigeno, Asako; Itakura, Yukari; Bell-Sakyi, Lesley; Edagawa, Shunji; Nagasaka, Atsushi; Sakoda, Yoshihiro; Sawa, Hirofumi; Maeda, Ken; Saijo, Masayuki; Matsuno, Keita

A novel nairovirus associated with acute febrile illness in Hokkaido, Japan

Kodama, Fumihiro; Yamaguchi, Hiroki; Park, Eunsil et al.

Nature communications, 2021, 12(1), 5539

Permalink : https://hdl.handle.net/2115/83176

このアイテムのアクセス数:505件（2026-08-16 05:19 集計）

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https://doi.org/10.1038/s41467-021-25857-0			32

論文情報

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アクセス権	open access
URI	https://hdl.handle.net/2115/83176
タイトル	A novel nairovirus associated with acute febrile illness in Hokkaido, Japan
著者	Kodama, Fumihiro ; Yamaguchi, Hiroki ; Park, Eunsil ; Tatemoto, Kango ; Sashika, Mariko ; Nakao, Ryo ; Terauchi, Yurino ; Mizuma, Keita ; Orba, Yasuko ; Kariwa, Hiroaki ; Hagiwara, Katsuro ; Okazaki, Katsunori ; Goto, Akiko ; Komagome, Rika ; Miyoshi, Masahiro ; Ito, Takuya ; Yamano, Kimiaki ; Yoshii, Kentaro ; Funaki, Chiaki ; Ishizuka, Mariko ; Shigeno, Asako ; Itakura, Yukari ; Bell-Sakyi, Lesley ; Edagawa, Shunji ; Nagasaka, Atsushi ; Sakoda, Yoshihiro ; Sawa, Hirofumi ; Maeda, Ken ; Saijo, Masayuki ; Matsuno, Keita
著者名 Kodama, Fumihiro
e-Rad_Researcher 50777836 著者名 Yamaguchi, Hiroki
e-Rad_Researcher 90750117 著者名 Park, Eunsil
著者名 Tatemoto, Kango
e-Rad_Researcher 30722954 著者名 Sashika, Mariko
e-Rad_Researcher 50633955 著者名 Nakao, Ryo
著者名 Terauchi, Yurino
著者名 Mizuma, Keita
e-Rad_Researcher 60507169 著者名 Orba, Yasuko
e-Rad_Researcher 70224714 著者名 Kariwa, Hiroaki
e-Rad_Researcher 50295896 著者名 Hagiwara, Katsuro
e-Rad_Researcher 90160663 著者名 Okazaki, Katsunori
e-Rad_Researcher 60414322 著者名 Goto, Akiko
e-Rad_Researcher 40414312 著者名 Komagome, Rika
e-Rad_Researcher 50414321 著者名 Miyoshi, Masahiro
著者名 Ito, Takuya
e-Rad_Researcher 40435566 著者名 Yamano, Kimiaki
e-Rad_Researcher 50421988 著者名 Yoshii, Kentaro
著者名 Funaki, Chiaki
著者名 Ishizuka, Mariko
著者名 Shigeno, Asako
著者名 Itakura, Yukari
著者名 Bell-Sakyi, Lesley
著者名 Edagawa, Shunji
著者名 Nagasaka, Atsushi
e-Rad_Researcher 40333637 著者名 Sakoda, Yoshihiro
e-Rad_Researcher 30292006 著者名 Sawa, Hirofumi
e-Rad_Researcher 90284273 著者名 Maeda, Ken
e-Rad_Researcher 50300926 著者名 Saijo, Masayuki
e-Rad_Researcher 40753306 著者名 Matsuno, Keita
言語	英語
発行日	2021-09-20
出版者	Nature Portfolio
収録物名	Nature communications
巻(号)	12(1)
ページ	5539
抄録	The increasing burden of tick-borne orthonairovirus infections, such as Crimean-Congo hemorrhagic fever, is becoming a global concern for public health. In the present study, we identify a novel orthonairovirus, designated Yezo virus (YEZV), from two patients showing acute febrile illness with thrombocytopenia and leukopenia after tick bite in Hokkaido, Japan, in 2019 and 2020, respectively. YEZV is phylogenetically grouped with Sulina virus detected in Ixodes ricinus ticks in Romania. YEZV infection has been confirmed in seven patients from 2014–2020, four of whom were co-infected with Borrelia spp. Antibodies to YEZV are found in wild deer and raccoons, and YEZV RNAs have been detected in ticks from Hokkaido. In this work, we demonstrate that YEZV is highly likely to be the causative pathogen of febrile illness, representing the first report of an endemic infection associated with an orthonairovirus potentially transmitted by ticks in Japan.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
PISSN	2041-1723
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1038/s41467-021-25857-0