Close association between non-alcoholic fatty liver disease and ossification of the posterior longitudinal ligament of the spine

Endo, Tsutomu; Koike, Yoshinao; Miyoshi, Hideaki; Hisada, Yuichiro; Fujita, Ryo; Suzuki, Ryota; Tanaka, Masaru; Tsujimoto, Takeru; Shimamura, Yukitoshi; Hasegawa, Yuichi; Kanayama, Masahiro; Hashimoto, Tomoyuki; Oha, Fumihiro; Noro, Naoki; Komano, Kiyofumi; Ishii, Misaki; Ito, Yoichi M.; Iwasaki, Norimasa; Takahata, Masahiko

Close association between non-alcoholic fatty liver disease and ossification of the posterior longitudinal ligament of the spine

Endo, Tsutomu; Koike, Yoshinao; Miyoshi, Hideaki et al.

Scientific reports, 2021, 11(1), 17412

Permalink : https://hdl.handle.net/2115/83190

このアイテムのアクセス数:623件（2026-08-14 19:35 集計）

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https://doi.org/10.1038/s41598-021-96714-9			12

論文情報

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アクセス権	open access
URI	https://hdl.handle.net/2115/83190
タイトル	Close association between non-alcoholic fatty liver disease and ossification of the posterior longitudinal ligament of the spine
著者	Endo, Tsutomu ; Koike, Yoshinao ; Miyoshi, Hideaki ; Hisada, Yuichiro ; Fujita, Ryo ; Suzuki, Ryota ; Tanaka, Masaru ; Tsujimoto, Takeru ; Shimamura, Yukitoshi ; Hasegawa, Yuichi ; Kanayama, Masahiro ; Hashimoto, Tomoyuki ; Oha, Fumihiro ; Noro, Naoki ; Komano, Kiyofumi ; Ishii, Misaki ; Ito, Yoichi M. ; Iwasaki, Norimasa ; Takahata, Masahiko
e-Rad_Researcher 90805293 著者名 Endo, Tsutomu
著者名 Koike, Yoshinao
e-Rad_Researcher 30360902 著者名 Miyoshi, Hideaki
著者名 Hisada, Yuichiro
著者名 Fujita, Ryo
著者名 Suzuki, Ryota
著者名 Tanaka, Masaru
著者名 Tsujimoto, Takeru
著者名 Shimamura, Yukitoshi
著者名 Hasegawa, Yuichi
著者名 Kanayama, Masahiro
著者名 Hashimoto, Tomoyuki
著者名 Oha, Fumihiro
著者名 Noro, Naoki
著者名 Komano, Kiyofumi
著者名 Ishii, Misaki
著者名 Ito, Yoichi M.
e-Rad_Researcher 30322803 著者名 Iwasaki, Norimasa
e-Rad_Researcher 40374368 著者名 Takahata, Masahiko
言語	英語
発行日	2021-08-31
出版者	Nature Portfolio
収録物名	Scientific reports
巻(号)	11(1)
ページ	17412
抄録	Ossification of the posterior longitudinal ligament (OPLL) of the spine is a disease of unknown etiology occurring frequently in individuals with metabolic disturbances. Obesity has been suggested as a potential risk factor for the severity of OPLL. We aimed to investigate whether non-alcoholic fatty liver disease (NAFLD) is associated with OPLL severity. We assessed the severity of NAFLD by a liver-to-spleen (L/S) ratio on computed tomography (CT) scans of 85 symptomatic OPLL patients at a single institution in Japan. We also assessed the severity of OPLL by CT reconstruction sagittal and axial images. The prevalence of NAFLD in middle-aged patients (age < 70 years, n = 50) was 80.3%, which was 2.5-8 times higher than that in the general Japanese population (9-30%). The ossification index of the spinal ligaments increased in proportion to the severity of fatty liver. The L/S ratio was revealed as a significant risk factor associated with the total ossification index (standardized beta: -0.40, 95% confidence interval - 54.34 to - 4.22). This study suggests the potential contribution of NAFLD to the progression of OPLL. The close association between NAFLD and OPLL demonstrated in this study warrants further study to elucidate the causal nature of this relationship.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
PISSN	2045-2322
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1038/s41598-021-96714-9