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論文情報

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アクセス権	open access
URI	https://hdl.handle.net/2115/83204
タイトル	Synthesis of Resolvin E3, a Proresolving Lipid Mediator, and Its Deoxy Derivatives : Identification of 18-Deoxy-resolvin E3 as a Potent Anti-Inflammatory Agent
著者	Fukuda, Hayato ; Ikeda, Hiroyuki ; Muromoto, Ryuta ; Hirashima, Koki ; Ishimura, Kohei ; Fujiwara, Koichi ; Aoki-Saito, Haruka ; Hisada, Takeshi ; Watanabe, Mizuki ; Ishihara, Jun ; Matsuda, Tadashi ; Shuto, Satoshi
著者名 Fukuda, Hayato
著者名 Ikeda, Hiroyuki
e-Rad_Researcher 30455597 著者名 Muromoto, Ryuta
著者名 Hirashima, Koki
著者名 Ishimura, Kohei
e-Rad_Researcher 40837853 著者名 Fujiwara, Koichi
著者名 Aoki-Saito, Haruka
著者名 Hisada, Takeshi
e-Rad_Researcher 20507173 著者名 Watanabe, Mizuki
著者名 Ishihara, Jun
e-Rad_Researcher 20212219 著者名 Matsuda, Tadashi
e-Rad_Researcher 70241346 著者名 Shuto, Satoshi
言語	英語
発行日	2020-11-06
出版者	American Chemical Society
収録物名	Journal of organic chemistry
巻(号)	85(21)
ページ	14190-14200
抄録	We synthesized RvE3 and its deoxy derivatives, 17-deoxy-RvE3 and 18-deoxy-RvE3, by a common route via Sonogashira coupling as a key step. The evaluation of their anti-inflammatory activities revealed that 18-deoxy-RvE3 was remarkably more potent than the parent RvE3 and significantly active at a 300 fg dose in mice; additionally, 17-deoxy-RvE3 was significantly less potent than the parent RvE3. For the first time, we found that the 17-hydroxy group of RvE3 is very important for anti-inflammatory activity.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	This document is the unedited Author’s version of a Submitted Work that was subsequently accepted for publication in Journal of organic chemistry, copyright c American Chemical Society after peer review. To access the final edited and published work see https://pubs.acs.org/doi/10.1021/acs.joc.0c01701.
PISSN	0022-3263
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1021/acs.joc.0c01701

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